Scholarlink

Objective <p>This study aimed to evaluate the efficacy of a single preoperative 15&#xa0;mg sublingual dose of melatonin in reducing surgical discomfort, pain, edema, and trismus following mandibular third molar extraction.</p> Materials and methods <p>A randomized, double-blind, placebo-controlled trial was conducted with 46 patients allocated to receive melatonin (<i>n</i> = 22) or placebo (<i>n</i> = 24) 45&#xa0;min before surgery. The primary outcomes were intraoperative pain and discomfort and postoperative pain. Secondary outcomes included patient-perceived edema (VAS-Edema, days 1–5), trismus (5-point scale, days 1–5; interincisal measurement, day 7), and rescue medication consumption.</p> Results <p>No statistically significant differences were observed between the melatonin and placebo groups for any outcome. Intraoperative discomfort (QCirDental total score, <i>p</i> = 0.54) and pain (VAS, <i>p</i> = 0.67) were comparable. Similarly, postoperative pain levels across all time points (<i>p</i> = 0.67), edema over five days (<i>p</i> = 0.26), and trismus based on self-assessment (all days <i>p</i> &gt; 0.50) and clinical measurement (<i>p</i> = 0.79) did not differ.</p> Conclusion <p>Within the limitations of this clinical trial, a single 15&#xa0;mg preoperative dose of sublingual melatonin was not superior to placebo in alleviating surgical discomfort, pain, edema, or trismus after third molar extraction.</p> Clinical relevance <p>Clinically, these findings suggest that melatonin may have limited effectiveness in managing common complications in oral surgery.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Preoperative 15 mg of melatonin for surgical discomfort, pain, edema and trismus in mandibular third molar surgery: a randomized double-blind placebo-controlled clinical trial

  • 期刊论文

  • 发表日期：

    2025年11月17日

查看全文
  • Carolina Ruppel,
  • Helen Heloene Rosa,
  • Renan Bordini Cardoso,
  • Natália Mariane Rigo,
  • Vanessa Carvajal Soto,
  • Marcelo Carlos Bortoluzzi

摘要

Objective

This study aimed to evaluate the efficacy of a single preoperative 15 mg sublingual dose of melatonin in reducing surgical discomfort, pain, edema, and trismus following mandibular third molar extraction.

Materials and methods

A randomized, double-blind, placebo-controlled trial was conducted with 46 patients allocated to receive melatonin (n = 22) or placebo (n = 24) 45 min before surgery. The primary outcomes were intraoperative pain and discomfort and postoperative pain. Secondary outcomes included patient-perceived edema (VAS-Edema, days 1–5), trismus (5-point scale, days 1–5; interincisal measurement, day 7), and rescue medication consumption.

Results

No statistically significant differences were observed between the melatonin and placebo groups for any outcome. Intraoperative discomfort (QCirDental total score, p = 0.54) and pain (VAS, p = 0.67) were comparable. Similarly, postoperative pain levels across all time points (p = 0.67), edema over five days (p = 0.26), and trismus based on self-assessment (all days p > 0.50) and clinical measurement (p = 0.79) did not differ.

Conclusion

Within the limitations of this clinical trial, a single 15 mg preoperative dose of sublingual melatonin was not superior to placebo in alleviating surgical discomfort, pain, edema, or trismus after third molar extraction.

Clinical relevance

Clinically, these findings suggest that melatonin may have limited effectiveness in managing common complications in oral surgery.