Scholarlink

Objectives <p>To evaluate periodontal health and its association with conditioning intensity over five years post-HCT.</p> Materials and methods <p>This multicentre prospective study included 104 patients from two Dutch centres. Probing pocket depth (PPD), bleeding on probing (BOP), and buccal gingival recession (GR) were assessed pre-HCT and at three (<i>n</i> = 34), six (<i>n</i> = 45), twelve (<i>n</i> = 46), eighteen months (<i>n</i> = 30), and five years (<i>n</i> = 36) post-HCT. Regression models evaluated associations with conditioning intensity and time since HCT.</p> Results <p>HCT recipients had a median age of 58 years; 56% were male, and 59% received an allogeneic transplant. At baseline, mean PPD was 2.3&#xa0;mm (31% had PPD ≥ 6&#xa0;mm), mean BOP was 23%, and the median number of teeth with GR ≥ 1&#xa0;mm was nine. Conditioning intensity was not significantly associated with PPD, GR, or BOP over time. Mean PPD decreased slightly at twelve months post-HCT (-0.21&#xa0;mm (95%CI -0.28, -0.14)) but increased marginally at five years (0.12&#xa0;mm (95%CI 0.08, 0.16)) compared to baseline. GR increased gradually with 0.13&#xa0;mm (95%CI 0.07, 0.19) at twelve months, and 0.16&#xa0;mm (95%CI 0.10, 0.23) at five years. BOP declined at twelve months (-11% (95%CI -15, -8)) but returned to baseline at five years (-1% (95%CI -5, 4)).</p> Conclusions <p>Our results suggest that conditioning intensity does not affect long-term periodontal health. Periodontal changes up to five years post-HCT were small.</p> Clinical relevance <p>Conditioning intensity may not be a key determinant of post-HCT periodontal health. Post-HCT periodontal deterioration was not found in our study.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

The effect of conditioning regimen intensity on periodontal health in haematopoietic cell transplantation recipients: a 5-year multicentre prospective cohort study

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年6月12日

查看全文
  • Lucky L.A. van Gennip,
  • Marjolein S. Bulthuis,
  • Renske Z. Thomas,
  • Ewald M. Bronkhorst,
  • Gerjon Hannink,
  • Alexa M.G.A. Laheij,
  • Judith E. Raber-Durlacher,
  • Frederik R. Rozema,
  • Michael T. Brennan,
  • Inger von Bültzingslöwen,
  • Nicole M.A. Blijlevens,
  • Stephanie J.M. van Leeuwen,
  • Marie-Charlotte D.N.J.M. Huysmans

摘要

Objectives

To evaluate periodontal health and its association with conditioning intensity over five years post-HCT.

Materials and methods

This multicentre prospective study included 104 patients from two Dutch centres. Probing pocket depth (PPD), bleeding on probing (BOP), and buccal gingival recession (GR) were assessed pre-HCT and at three (n = 34), six (n = 45), twelve (n = 46), eighteen months (n = 30), and five years (n = 36) post-HCT. Regression models evaluated associations with conditioning intensity and time since HCT.

Results

HCT recipients had a median age of 58 years; 56% were male, and 59% received an allogeneic transplant. At baseline, mean PPD was 2.3 mm (31% had PPD ≥ 6 mm), mean BOP was 23%, and the median number of teeth with GR ≥ 1 mm was nine. Conditioning intensity was not significantly associated with PPD, GR, or BOP over time. Mean PPD decreased slightly at twelve months post-HCT (-0.21 mm (95%CI -0.28, -0.14)) but increased marginally at five years (0.12 mm (95%CI 0.08, 0.16)) compared to baseline. GR increased gradually with 0.13 mm (95%CI 0.07, 0.19) at twelve months, and 0.16 mm (95%CI 0.10, 0.23) at five years. BOP declined at twelve months (-11% (95%CI -15, -8)) but returned to baseline at five years (-1% (95%CI -5, 4)).

Conclusions

Our results suggest that conditioning intensity does not affect long-term periodontal health. Periodontal changes up to five years post-HCT were small.

Clinical relevance

Conditioning intensity may not be a key determinant of post-HCT periodontal health. Post-HCT periodontal deterioration was not found in our study.