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Objectives <p>This study investigated the effect of Selcopintide (SCPT) on periodontal regeneration using surgically created class II furcation defects in an animal model, employing both radiographical and histological evaluations.</p> Materials and methods <p>Class II furcation defects were surgically induced in six beagle dogs. Each defect was unilaterally and randomly assigned to one of five treatment groups: (1) no treatment (control), (2) guided tissue regeneration (GTR) with a collagenated bone substitute and a collagen membrane, (3) GTR with an enamel matrix derivative (GTR/EMD), (4) GTR with 2&#xa0;mg/ml SCPT (GTR/SCPT2), or (5) GTR with 4&#xa0;mg/ml SCPT (GTR/SCPT4). Six weeks after initial surgery, identical procedures were performed on the contralateral area. Healing outcomes were assessed at 6 and 12 weeks through radiographic and histomorphometric analyses. The primary outcome was the length of the root surface covered by new cementum assessed histologically and the secondary outcome included other histomorphometric and radiographic healing outcomes.</p> Results <p>Radiographically, the GTR/SCPT groups showed significantly greater new bone volume than the control group at both 6- and 12-week timepoints (<i>p</i> &lt; 0.05). Histologically, specimens treated with both formulations of SCPT displayed better-organized periodontal ligaments and improved cementum formation, similar to those treated with EMD. The group with the highest concentration of SCPT (GTR/SCPT4) exhibited the greatest amount of new cementum formation.</p> Conclusions <p>Within the limitations of this study, both formulations of SCPT demonstrated significant regenerative potential in periodontal tissues, with outcomes comparable to those of EMD treatment, suggesting SCPT’s viability as an alternative bioactive agent for periodontal regeneration in class II furcation defects.</p> Clinical relevance <p>This study suggests that SCPT could serve as a viable alternative bioactive agent for periodontal regeneration in class II furcation defect in clinical settings.</p>

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The impact of selcopintide on periodontal regeneration in a class II furcation defect model: a radiographic and histomorphometric analysis

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年4月24日

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  • Jungwoo Jung,
  • Jungwon Lee,
  • Seunghee Lee,
  • Ki-Tae Koo,
  • Yang-Jo Seol,
  • Joo-Cheol Park,
  • Jeongmin Park,
  • Su-Jin Park,
  • Chul Son,
  • Seong Min Roh,
  • Jin-Seok Seo,
  • Yong-Moo Lee

摘要

Objectives

This study investigated the effect of Selcopintide (SCPT) on periodontal regeneration using surgically created class II furcation defects in an animal model, employing both radiographical and histological evaluations.

Materials and methods

Class II furcation defects were surgically induced in six beagle dogs. Each defect was unilaterally and randomly assigned to one of five treatment groups: (1) no treatment (control), (2) guided tissue regeneration (GTR) with a collagenated bone substitute and a collagen membrane, (3) GTR with an enamel matrix derivative (GTR/EMD), (4) GTR with 2 mg/ml SCPT (GTR/SCPT2), or (5) GTR with 4 mg/ml SCPT (GTR/SCPT4). Six weeks after initial surgery, identical procedures were performed on the contralateral area. Healing outcomes were assessed at 6 and 12 weeks through radiographic and histomorphometric analyses. The primary outcome was the length of the root surface covered by new cementum assessed histologically and the secondary outcome included other histomorphometric and radiographic healing outcomes.

Results

Radiographically, the GTR/SCPT groups showed significantly greater new bone volume than the control group at both 6- and 12-week timepoints (p < 0.05). Histologically, specimens treated with both formulations of SCPT displayed better-organized periodontal ligaments and improved cementum formation, similar to those treated with EMD. The group with the highest concentration of SCPT (GTR/SCPT4) exhibited the greatest amount of new cementum formation.

Conclusions

Within the limitations of this study, both formulations of SCPT demonstrated significant regenerative potential in periodontal tissues, with outcomes comparable to those of EMD treatment, suggesting SCPT’s viability as an alternative bioactive agent for periodontal regeneration in class II furcation defects.

Clinical relevance

This study suggests that SCPT could serve as a viable alternative bioactive agent for periodontal regeneration in class II furcation defect in clinical settings.