Correlation of Porphyromonas gingivalis with esophageal squamous cell carcinoma: a systematic review

This study aimed to assess the correlation of Porphyromonas gingivalis (P. gingivalis) with esophageal squamous cell carcinoma (ESCC).

This systematic review evaluated case-control, cohort, and cross-sectional studies published between 1990 and 2024 that compared ESCC patients and healthy controls regarding the presence of P. gingivalis, risk of ESCC development, overall survival rate and prognosis of ESCC, lymph node metastasis, clinical stage of the disease, cancer cell proliferation and migration, efficacy of chemotherapy, invasion depth, and cell differentiation. Searching process was conducted in Web of Science, Scopus, PubMed, and Cochrane Library. The quality of included studies was assessed by the Newcastle Ottawa scale (NOS).

Of 270 articles, 11 underwent a systematic review with NOS scores ranging from 7 to 9. 5 studies found a correlation between P.gingivalis and overall survival rate of ESCC patients (P < 0.05). 5 studies found a significant correlation between P.gingivalis count and the risk of ESCC development (P < 0.05). 2 studies showed a significant correlation between lymph node metastasis and 3 studies showed a significant correlation between clinical TNM stage and P.gingivalis (P < 0.05).

High P. gingivalis count increases the risk of development of ESCC, lymph node metastasis, progression to stages 3 and 4, proliferation and migration of cancer cells, and depth of invasion, decreases the overall survival rate and prognosis of the disease, and efficacy of chemotherapy, and results in poorer differentiation of cells.

According to our findings, dental clinicians and patients should be informed about the significance of oral hygiene and its relationship with ESCC to prevent future life-threatening diseases.