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Introduction <p>Diffuse idiopathic skeletal hyperostosis (DISH) primarily affects the axial skeleton, but its association with hip osteoarthritis (OA) remains unclear. We investigated the prevalence and 5&#xa0;year progression of hip OA in individuals with DISH and explored risk factors for progression.</p> Materials and methods <p>This retrospective cohort study reviewed 694 asymptomatic individuals who underwent whole-body computed tomography (CT) for cancer screening (2016–2023) and had follow-up CT at ≥ 5&#xa0;years. DISH was diagnosed using CT-based criteria. We identified 143 individuals with DISH and selected 143 age- and sex-matched controls without DISH (1:1). Hip OA was assessed using a CT-based composite score (0–14, bilateral). Radiographic hip OA was defined as a bilateral score ≥ 10, and progression as an increase of ≥ 2 points over 5&#xa0;years. Multivariable regression analyses were performed to identify independent predictors of progression.</p> Results <p>The DISH group had higher total hip OA scores and a higher prevalence of radiographic hip OA than controls at baseline and follow-up. However, OA progression rates did not differ significantly between groups. Among individuals with DISH, the number of ankylosed vertebral segments was independently associated with hip OA progression.</p> Conclusion <p>Individuals with DISH show a higher prevalence of radiographic hip OA. Extensive spinal ankylosis may increase the risk of hip OA progression, supporting the need for longitudinal monitoring of hip joint health in DISH.</p>

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Prevalence and progression of hip osteoarthritis in individuals with diffuse idiopathic skeletal hyperostosis

  • 期刊论文

  • 发表日期：

    2026年4月11日

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  • Masaya Kubota,
  • Takayoshi Shimizu,
  • Masaki Sakamoto,
  • Masahiro Yakami,
  • Takashi Sono,
  • Ryusuke Nakamoto,
  • Shuichi Matsuda,
  • Bungo Otsuki

摘要

Introduction

Diffuse idiopathic skeletal hyperostosis (DISH) primarily affects the axial skeleton, but its association with hip osteoarthritis (OA) remains unclear. We investigated the prevalence and 5 year progression of hip OA in individuals with DISH and explored risk factors for progression.

Materials and methods

This retrospective cohort study reviewed 694 asymptomatic individuals who underwent whole-body computed tomography (CT) for cancer screening (2016–2023) and had follow-up CT at ≥ 5 years. DISH was diagnosed using CT-based criteria. We identified 143 individuals with DISH and selected 143 age- and sex-matched controls without DISH (1:1). Hip OA was assessed using a CT-based composite score (0–14, bilateral). Radiographic hip OA was defined as a bilateral score ≥ 10, and progression as an increase of ≥ 2 points over 5 years. Multivariable regression analyses were performed to identify independent predictors of progression.

Results

The DISH group had higher total hip OA scores and a higher prevalence of radiographic hip OA than controls at baseline and follow-up. However, OA progression rates did not differ significantly between groups. Among individuals with DISH, the number of ankylosed vertebral segments was independently associated with hip OA progression.

Conclusion

Individuals with DISH show a higher prevalence of radiographic hip OA. Extensive spinal ankylosis may increase the risk of hip OA progression, supporting the need for longitudinal monitoring of hip joint health in DISH.