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<p>Serous tubal intraepithelial carcinoma (STIC) is most often detected incidentally during risk-reducing salpingo-oophorectomy (RRSO) in patients at an increased risk of breast and ovarian cancer. It is considered to be an early tubal precursor lesion of high-grade serous carcinoma (HGSC) of the tube, ovary, and peritoneum. To date, there are no general guidelines. Pathological assessment of the tubes should follow the SEE-FIM (<i>s</i>ectioning and <i>e</i>xtensively <i>e</i>xamining the <i>fim</i>briated end) protocol. A&#xa0;laparoscopic staging procedure is frequently performed, although its clinical benefit remains uncertain. Adjuvant therapy is generally not required. Opportunistic salpingectomy, i.e., the additional removal of the fallopian tubes after completion of childbearing, represents a&#xa0;key preventive strategy to significantly reduce the risk of tubo-ovarian HGSC. In cases of incidental STIC detection, genetic counseling and/or testing are recommended. Future registry data are expected to support the development of standardized recommendations.</p>

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Seröses tubares intraepitheliales Karzinom – Diagnostik, Prävention und Management

  • 期刊论文

  • 发表日期：

    2026年4月1日

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  • Valerie Catherine Linz,
  • Sebastian Försch,
  • Annette Hasenburg

摘要

Serous tubal intraepithelial carcinoma (STIC) is most often detected incidentally during risk-reducing salpingo-oophorectomy (RRSO) in patients at an increased risk of breast and ovarian cancer. It is considered to be an early tubal precursor lesion of high-grade serous carcinoma (HGSC) of the tube, ovary, and peritoneum. To date, there are no general guidelines. Pathological assessment of the tubes should follow the SEE-FIM (sectioning and extensively examining the fimbriated end) protocol. A laparoscopic staging procedure is frequently performed, although its clinical benefit remains uncertain. Adjuvant therapy is generally not required. Opportunistic salpingectomy, i.e., the additional removal of the fallopian tubes after completion of childbearing, represents a key preventive strategy to significantly reduce the risk of tubo-ovarian HGSC. In cases of incidental STIC detection, genetic counseling and/or testing are recommended. Future registry data are expected to support the development of standardized recommendations.