Scholarlink

<p>Testicular germ cell tumors are the most common malignant neoplasms in young men and are characterized by high cure rates as well as complex pathology. Diagnostic evaluation has traditionally relied on histomorphology, immunohistochemistry (IHC), and classical serum tumor markers (alpha-fetoprotein, AFP; beta-human chorionic gonadotropin, β‑hCG; lactate dehydrogenase, LDH). The fifth&#xa0;edition of the World Health Organization (WHO) classification (2022) further refined the terminology and defined new entities. In parallel, the microRNA (mRNA) miR-371a-3p has been established as a&#xa0;sensitive and specific “liquid biopsy” marker for the diagnosis of germ cell tumors. This review summarizes current pathobiological concepts, the updates of the 2022 WHO classification, and the role of miRNA-based diagnostics in clinical practice.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Pathologie der Keimzelltumoren: aktuelle Klassifikation und Biomarker

  • 期刊论文

  • 发表日期：

    2026年2月6日

查看全文
  • Martin Zielke,
  • Alexander Fichtner,
  • Felix Bremmer,
  • Tim Nestler

摘要

Testicular germ cell tumors are the most common malignant neoplasms in young men and are characterized by high cure rates as well as complex pathology. Diagnostic evaluation has traditionally relied on histomorphology, immunohistochemistry (IHC), and classical serum tumor markers (alpha-fetoprotein, AFP; beta-human chorionic gonadotropin, β‑hCG; lactate dehydrogenase, LDH). The fifth edition of the World Health Organization (WHO) classification (2022) further refined the terminology and defined new entities. In parallel, the microRNA (mRNA) miR-371a-3p has been established as a sensitive and specific “liquid biopsy” marker for the diagnosis of germ cell tumors. This review summarizes current pathobiological concepts, the updates of the 2022 WHO classification, and the role of miRNA-based diagnostics in clinical practice.