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Background <p>Testicular germ cell tumors commonly affect young men under the age of&#xa0;40. Even in metastatic stages, the cure rates are excellent; hence, the number of testicular cancer survivors is increasing steadily.</p> Objective <p>This article presents a discussion of the current evidence regarding chemotherapy-associated long-term toxicities as well as an overview of aspects relevant for testicular cancer patient survivorship care in clinical practice.</p> Materials and methods <p>A&#xa0;narrative review was constructed based on a&#xa0;selective literature search of the PubMed database to summarize the available evidence regarding long-term treatment side effects and their implications for survivorship care recommendations for testicular cancer survivors.</p> Results <p>Cisplatin-based chemotherapy is associated with a&#xa0;variety of long-term toxicities, of which some are highly relevant for long-term follow-up and survivorship care. Specifically, there is an increased risk of developing metabolic syndrome, cardiovascular events, and treatment-related secondary cancer. Further common long-term side effects include chronically reduced kidney function, sensory polyneuropathy, impaired hearing, hypogonadism, and infertility as well as chronic fatigue, anxiety disorders, and depression.</p> Conclusion <p>Standard follow-up care after successful treatment generally concludes after 5&#xa0;years, but the mentioned side effects are generally of life-long significance for germ cell tumor patients. Hence, awareness, prevention, and early detection of such long-term effects are of critical importance to maintain quality of life, general health, and a&#xa0;normal life expectancy.</p>

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Langzeittoxizitäten bei Keimzelltumorüberlebenden

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年2月11日

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  • Christoph Oing,
  • Christoph Seidel,
  • Carsten Bokemeyer

摘要

Background

Testicular germ cell tumors commonly affect young men under the age of 40. Even in metastatic stages, the cure rates are excellent; hence, the number of testicular cancer survivors is increasing steadily.

Objective

This article presents a discussion of the current evidence regarding chemotherapy-associated long-term toxicities as well as an overview of aspects relevant for testicular cancer patient survivorship care in clinical practice.

Materials and methods

A narrative review was constructed based on a selective literature search of the PubMed database to summarize the available evidence regarding long-term treatment side effects and their implications for survivorship care recommendations for testicular cancer survivors.

Results

Cisplatin-based chemotherapy is associated with a variety of long-term toxicities, of which some are highly relevant for long-term follow-up and survivorship care. Specifically, there is an increased risk of developing metabolic syndrome, cardiovascular events, and treatment-related secondary cancer. Further common long-term side effects include chronically reduced kidney function, sensory polyneuropathy, impaired hearing, hypogonadism, and infertility as well as chronic fatigue, anxiety disorders, and depression.

Conclusion

Standard follow-up care after successful treatment generally concludes after 5 years, but the mentioned side effects are generally of life-long significance for germ cell tumor patients. Hence, awareness, prevention, and early detection of such long-term effects are of critical importance to maintain quality of life, general health, and a normal life expectancy.