Scholarlink

<p>Renal replacement therapy (RRT) is an indispensable component of modern intensive care. In the extracorporeal circuit, the interaction of blood with artificial surfaces activates hemostasis, increasing the risk of premature filter clotting. This review examines regional citrate anticoagulation (RCA), which has emerged as an effective and safe standard approach to anticoagulation for continuous modalities. RCA reduces bleeding complications and prolongs filter life, although no clear mortality benefit over other anticoagulation strategies has been demonstrated to date. Special clinical situations such as citrate accumulation, filter clogging, and heparin-induced thrombocytopenia (HIT) are also addressed. Owing to its greater complexity, the technique requires close monitoring and adequate staff training. When these conditions are met, RCA is a&#xa0;valuable tool for optimizing RRT.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Regionale Antikoagulation bei Nierenersatztherapie auf der Intensivstation

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年3月2日

查看全文
  • Michael Schmitz

摘要

Renal replacement therapy (RRT) is an indispensable component of modern intensive care. In the extracorporeal circuit, the interaction of blood with artificial surfaces activates hemostasis, increasing the risk of premature filter clotting. This review examines regional citrate anticoagulation (RCA), which has emerged as an effective and safe standard approach to anticoagulation for continuous modalities. RCA reduces bleeding complications and prolongs filter life, although no clear mortality benefit over other anticoagulation strategies has been demonstrated to date. Special clinical situations such as citrate accumulation, filter clogging, and heparin-induced thrombocytopenia (HIT) are also addressed. Owing to its greater complexity, the technique requires close monitoring and adequate staff training. When these conditions are met, RCA is a valuable tool for optimizing RRT.