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<p>Fatigue is described as a&#xa0;subjective feeling of physical and/or mental exhaustion that is perceived as a&#xa0;hindrance for desired activities and has a&#xa0;negative impact on the quality of life. Depending on the disease, 35–59% of individuals with neurological disorders are affected. The pathophysiological mechanisms of fatigue are not fully understood. A&#xa0;wide range of definitions and assessment scales have been developed for fatigue in general as well as in relation to specific neurological disorders. Fatigue frequently co-occurs with other emotional, cognitive and physical consequences of neurological diseases and shows complex interactions with these symptoms. All these factors, together with the complexity of the described symptoms, contribute to a&#xa0;heterogeneity that complicates the diagnosis and, consequently, the development of specifically effective interventions. Recent approaches propose interdisciplinary, transdiagnostic approaches for treatment as well as the classification of symptoms into clusters or phenotypes, to facilitate the development of patient-adjusted treatment.</p>

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Fatigue bei neurologischen Erkrankungen

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年2月23日

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  • Yvonne Teuschl,
  • Doaa Al-Mamoori,
  • Walter Struhal

摘要

Fatigue is described as a subjective feeling of physical and/or mental exhaustion that is perceived as a hindrance for desired activities and has a negative impact on the quality of life. Depending on the disease, 35–59% of individuals with neurological disorders are affected. The pathophysiological mechanisms of fatigue are not fully understood. A wide range of definitions and assessment scales have been developed for fatigue in general as well as in relation to specific neurological disorders. Fatigue frequently co-occurs with other emotional, cognitive and physical consequences of neurological diseases and shows complex interactions with these symptoms. All these factors, together with the complexity of the described symptoms, contribute to a heterogeneity that complicates the diagnosis and, consequently, the development of specifically effective interventions. Recent approaches propose interdisciplinary, transdiagnostic approaches for treatment as well as the classification of symptoms into clusters or phenotypes, to facilitate the development of patient-adjusted treatment.