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Purpose <p>Postpartum depression (PPD), the most common childbirth complication in the United States, can be treated using brexanolone, an intravenous form of allopregnanolone.</p> Methods <p>This retrospective chart review study evaluated clinical outcomes of 64 postpartum women who received brexanolone infusion for PPD in a real-world setting.</p> Results <p>Treatment was associated with improved depression and anxiety symptoms, and 71% of patients reported significant improvement in their PPD.</p> Conclusions <p>While further research is needed, this study supports brexanolone as an efficacious treatment for PPD.</p>

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A retrospective chart review study of patients treated in a hospital-based brexanolone program

  • 期刊论文

  • 发表日期：

    2025年5月2日

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  • Zobeida M. Diaz,
  • Margaret M. Howard,
  • Keyline V. Moreno,
  • Madilyn G. Halwes,
  • Cynthia L. Battle

摘要

Purpose

Postpartum depression (PPD), the most common childbirth complication in the United States, can be treated using brexanolone, an intravenous form of allopregnanolone.

Methods

This retrospective chart review study evaluated clinical outcomes of 64 postpartum women who received brexanolone infusion for PPD in a real-world setting.

Results

Treatment was associated with improved depression and anxiety symptoms, and 71% of patients reported significant improvement in their PPD.

Conclusions

While further research is needed, this study supports brexanolone as an efficacious treatment for PPD.