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Purpose <p>There is limited high-quality evidence about perinatal mental health among women with gestational diabetes. We aimed to assess the risks and longitudinal changes in anxiety, depression, and health-related quality of life comparing women with gestational diabetes and those without among a contemporary cohort of pregnant women.</p> Methods <p>Prospective cohort study of participants in the GEMS Trial. Women with a singleton pregnancy were eligible if they had a 75-g diagnostic oral glucose-tolerance test between 24 and 32 weeks’ gestation, provided written informed consent, and completed questionnaires about anxiety, depression, and health-related quality of life at the study time points.</p> Results <p>There were no differences in risk for anxiety (RR 1.13, 95% CI 0.86, 1.49; <i>p</i> = 0.39) or depression (RR 1.08, 95% CI 0.78, 1.50; <i>p</i> = 0.64) between the two groups at 36 weeks’ gestation or 6 months postpartum [anxiety: (RR 1.21, 95% CI 0.90, 1.63; <i>p</i> = 0.21); depression: (RR 0.84, 95% CI 0.55, 1.28; <i>p</i> = 0.43]. However, at 36 weeks’ gestation participants with gestational diabetes reported better physical functioning, and at 6 months postpartum, better mental functioning (mean difference (MD) in scores 1.28, 95% CI 0.25, 2.30; <i>p</i> = 0.01) although worse physical functioning (MD -2.99, 95% CI -3.90, -2.07; p = &lt; 0.001) compared to participants without.</p> Conclusion <p>The risk for poor mental health during the perinatal period does not differ importantly among women diagnosed and treated for gestational diabetes compared to the general pregnant population.</p>

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Gestational diabetes and mental health: longitudinal analysis of data from the GEMS randomized trial

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年1月15日

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  • Phyllis Ohene-Agyei,
  • Greg D. Gamble,
  • Thach Tran,
  • Jane E. Harding,
  • Caroline A. Crowther

摘要

Purpose

There is limited high-quality evidence about perinatal mental health among women with gestational diabetes. We aimed to assess the risks and longitudinal changes in anxiety, depression, and health-related quality of life comparing women with gestational diabetes and those without among a contemporary cohort of pregnant women.

Methods

Prospective cohort study of participants in the GEMS Trial. Women with a singleton pregnancy were eligible if they had a 75-g diagnostic oral glucose-tolerance test between 24 and 32 weeks’ gestation, provided written informed consent, and completed questionnaires about anxiety, depression, and health-related quality of life at the study time points.

Results

There were no differences in risk for anxiety (RR 1.13, 95% CI 0.86, 1.49; p = 0.39) or depression (RR 1.08, 95% CI 0.78, 1.50; p = 0.64) between the two groups at 36 weeks’ gestation or 6 months postpartum [anxiety: (RR 1.21, 95% CI 0.90, 1.63; p = 0.21); depression: (RR 0.84, 95% CI 0.55, 1.28; p = 0.43]. However, at 36 weeks’ gestation participants with gestational diabetes reported better physical functioning, and at 6 months postpartum, better mental functioning (mean difference (MD) in scores 1.28, 95% CI 0.25, 2.30; p = 0.01) although worse physical functioning (MD -2.99, 95% CI -3.90, -2.07; p = < 0.001) compared to participants without.

Conclusion

The risk for poor mental health during the perinatal period does not differ importantly among women diagnosed and treated for gestational diabetes compared to the general pregnant population.