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First episode depression during the perinatal period is associated with atopic diseases and persistently increased eosinophil and basophil levels

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2024年10月16日

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  • En-Young N. Wagner,
  • Eva Maria Pichler,
  • Mario Müller,
  • Andrea Eisenhut,
  • Ana Buadze,
  • Yanhua Xu,
  • Erich Seifritz,
  • Marie-Pierre F. Strippoli,
  • Enrique Castelao,
  • Setareh Ranjbar,
  • Jennifer Glaus,
  • Caroline Vandeleur,
  • Martin Preisig,
  • Roland von Känel,
  • Vladeta Ajdacic-Gross

摘要

Purpose

A previous diagnosis of depression is a strong predictor for perinatal depression, apart from other mental disorders, stress, and atopies. It is less clear which factors interfere if perinatal depression occurs as a first depression episode (fePND).

Methods

We examined the associations with atopies and related blood parameters using data of CoLaus|PsyCoLaus.

Results

Newly occurring depression during the perinatal period but not recurrent depression was associated with a lifetime diagnosis of allergies and asthma together with persistently increased levels of basophils and eosinophils.

Conclusion

The results imply that immune function may play a relevant role in the risk of a fePND. If confirmed and detailed, these findings could serve as the basis for designing preliminary prevention strategies by observing eosinophil and basophil levels as well as symptoms of atopic diseases before/during pregnancy.