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<p>Early and accurate acute kidney injury (AKI) diagnosis in magnetic resonance imaging (MRI) is highly limited by the low contrast efficiency and potential toxicity of clinical contrast agents. Herein, we loaded Gd-DTPA by Ruthenium nanoparticles (RuNP) to achieve accurate diagnosis of AKI. The RuNP loaded Gd-DTPA (RuNPGd) show more efficient acceleration on the longitudinal (<i>T</i><sub>1</sub>) relxation of proton due to the increased weight, which significantly increase the molecular tumbling time (τ<sub>R</sub>). Besides, RuNP mimic multi-enzyme activities and effectively eliminate the metal-induced reactive oxygen species (ROS). In vivo study indicate that the MRI signals of kidneys of AKI mouse is significantly stronger than that of health mouse after intravenous injection of RuNPGd. Moreover, the administration of the RuNPGd would not aggravate renal damage of AKI owing to the ROS scavenging capacity. This new MRI contrast agent, that show high biocompatibility and <i>T</i><sub>1</sub> contrast capacity, provide a new tool to achieve accurate AKI diagnosis.</p>

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Ruthenium nanoparticles loaded Gd-DTPA with self-purification capacity for acute kidney injury

  • 期刊论文

  • 发表日期：

    2026年2月27日

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  • Guangyang Xiang,
  • Meiying Wan,
  • Yang Qiu,
  • Xi Ye,
  • Bo Huang

摘要

Early and accurate acute kidney injury (AKI) diagnosis in magnetic resonance imaging (MRI) is highly limited by the low contrast efficiency and potential toxicity of clinical contrast agents. Herein, we loaded Gd-DTPA by Ruthenium nanoparticles (RuNP) to achieve accurate diagnosis of AKI. The RuNP loaded Gd-DTPA (RuNPGd) show more efficient acceleration on the longitudinal (T1) relxation of proton due to the increased weight, which significantly increase the molecular tumbling time (τR). Besides, RuNP mimic multi-enzyme activities and effectively eliminate the metal-induced reactive oxygen species (ROS). In vivo study indicate that the MRI signals of kidneys of AKI mouse is significantly stronger than that of health mouse after intravenous injection of RuNPGd. Moreover, the administration of the RuNPGd would not aggravate renal damage of AKI owing to the ROS scavenging capacity. This new MRI contrast agent, that show high biocompatibility and T1 contrast capacity, provide a new tool to achieve accurate AKI diagnosis.