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<p>Acute anterior uveitis (AAU) associated with human leukocyte antigen (HLA) B27 is the most common form of noninfectious intraocular inflammation and is considered to be a&#xa0;separate clinical entity. Young adults between the ages of&#xa0;20 and&#xa0;40 years are predominantly affected. The HLA-B27 positive AAU typically presents as a&#xa0;unilateral, fulminant disruption of the blood-aqueous humor barrier, which is accompanied by pronounced cellular infiltration and fibrinous exudation. Other characteristics are reduced intraocular pressure and a&#xa0;high tendency to relapse, which can also involve the partner eye. Patients with HLA-B27 positive AAU share a&#xa0;high risk for other genetically associated diseases, especially spondylarthritis, chronic inflammatory bowel diseases and psoriasis. As up to 40% of those affected have a&#xa0;systemic disease that has not yet been diagnosed, the ophthalmologist is of major importance for early detection.</p> Graphic abstract <p></p>

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HLA-B27-positive Uveitis anterior

  • 期刊论文

  • 发表日期：

    2025年11月12日

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  • Peter Werkl,
  • Judith Rademacher,
  • Uwe Pleyer

摘要

Acute anterior uveitis (AAU) associated with human leukocyte antigen (HLA) B27 is the most common form of noninfectious intraocular inflammation and is considered to be a separate clinical entity. Young adults between the ages of 20 and 40 years are predominantly affected. The HLA-B27 positive AAU typically presents as a unilateral, fulminant disruption of the blood-aqueous humor barrier, which is accompanied by pronounced cellular infiltration and fibrinous exudation. Other characteristics are reduced intraocular pressure and a high tendency to relapse, which can also involve the partner eye. Patients with HLA-B27 positive AAU share a high risk for other genetically associated diseases, especially spondylarthritis, chronic inflammatory bowel diseases and psoriasis. As up to 40% of those affected have a systemic disease that has not yet been diagnosed, the ophthalmologist is of major importance for early detection.

Graphic abstract