Scholarlink

Purpose <p>The present study aimed to compare the results of the Schirmer test over time between the eyes of healthy participants and those with aqueous-deficient dry eye (ADDE) and to calculate the diagnostic cut-off values.</p> Methods <p>An observational cross-sectional study was carried out with 20 healthy volunteers and 20 patients with ADDE who fulfilled the inclusion/exclusion criteria (40&#xa0;eyes/group). A&#xa0;digital photograph was taken of each strip in both eyes simultaneously every minute during a&#xa0;Schirmer test procedure until the test ended (minutes&#xa0;1, 2, 3, 4, and 5). Results from the strips were measured by a&#xa0;masked observer using ImageJ software and compared between the two groups.</p> Results <p>There was a&#xa0;difference in the Schirmer test results for the various time points in all analyses between the two groups (Greenhouse–Geisser, both <i>p</i> ≤ 0.001; Sidak, all <i>p</i> ≤ 0.001). In the pairwise analysis of each time point, there was a&#xa0;difference in Schirmer values between the groups (unpaired <i>t</i> test, all <i>p</i> ≤ 0.001). There was no inter-eye difference in Schirmer absolute values between time points for both groups (Friedman, both <i>p</i> ≥ 0.090; Wilcoxon, all <i>p</i> ≥ 0.062), except for the first vs. the fourth and fifth time points in the ADDE participants (Wilcoxon, both <i>p</i> ≤ 0.030). In the pairwise analysis of each time point, there was a&#xa0;difference in inter-eye absolute values between the groups (unpaired <i>t</i> test, all <i>p</i> ≤ 0.010), except for the fourth vs. the final time point (Mann–Whitney, both <i>p</i> ≥ 0.414).</p> Conclusion <p>A&#xa0;complete report of the progression of Schirmer test values over time and between the eyes of healthy participants and ADDE patients is presented here, along with the cut-off criteria for the different time points studied.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Comparison of Schirmer test values between patients with aqueous deficient dry eye and healthy participants

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年3月10日

查看全文
  • Hugo Pena-Verdeal,
  • Jacobo Garcia-Queiruga,
  • Belen Sabucedo-Villamarin,
  • Carlos García-Resúa,
  • Maria J. Giraldez,
  • Eva Yebra-Pimentel

摘要

Purpose

The present study aimed to compare the results of the Schirmer test over time between the eyes of healthy participants and those with aqueous-deficient dry eye (ADDE) and to calculate the diagnostic cut-off values.

Methods

An observational cross-sectional study was carried out with 20 healthy volunteers and 20 patients with ADDE who fulfilled the inclusion/exclusion criteria (40 eyes/group). A digital photograph was taken of each strip in both eyes simultaneously every minute during a Schirmer test procedure until the test ended (minutes 1, 2, 3, 4, and 5). Results from the strips were measured by a masked observer using ImageJ software and compared between the two groups.

Results

There was a difference in the Schirmer test results for the various time points in all analyses between the two groups (Greenhouse–Geisser, both p ≤ 0.001; Sidak, all p ≤ 0.001). In the pairwise analysis of each time point, there was a difference in Schirmer values between the groups (unpaired t test, all p ≤ 0.001). There was no inter-eye difference in Schirmer absolute values between time points for both groups (Friedman, both p ≥ 0.090; Wilcoxon, all p ≥ 0.062), except for the first vs. the fourth and fifth time points in the ADDE participants (Wilcoxon, both p ≤ 0.030). In the pairwise analysis of each time point, there was a difference in inter-eye absolute values between the groups (unpaired t test, all p ≤ 0.010), except for the fourth vs. the final time point (Mann–Whitney, both p ≥ 0.414).

Conclusion

A complete report of the progression of Schirmer test values over time and between the eyes of healthy participants and ADDE patients is presented here, along with the cut-off criteria for the different time points studied.