Scholarlink

<p>Madhumukthi Kudineer Chooranum (MKC) is a decoction from polyherbal Siddha formulation for managing diabetes. The safety of this formulation has not been reported earlier. This study evaluates the chronic toxicity of the Siddha herbal formulation MKC in experimental Sprague–Dawley (SD)&#xa0;rats. In an acute oral toxicity study, male and female SD rats were orally administered a single dose of MKC (2000&#xa0;mg/kg), and clinical signs and mortality stages were observed for 14&#xa0;days along with weekly body weight. On day 15, the rats were euthanized and the gross morphology was carried out during necropsy. In a chronic (repeated dose) oral toxicity study, the male and female rats were orally administered MKC (200, 400, and 800&#xa0;mg/kg) once daily for up to 180&#xa0;days. MKC showed outstanding tolerance in SD rats with a NOAEL of 2000 mg/kg, with no adverse effects or death during the study. In acute and chronic toxicity trials, MKC did not alter parameters or cause harmful effects. No group died or became moribund in either study.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Acute and chronic toxicity study for Madhumukthi Kudineer Chooranum

  • 期刊论文

  • 发表日期：

    2025年4月3日

查看全文
  • Rajamanickam Baskar,
  • Govindaraju Bharathkumar,
  • Yovas Rajammal Manekshah,
  • Sikkal Selvaraaju Selvapriya,
  • Thangarasu Hema Devi,
  • Selvaraj Bharathi,
  • Kuppuswamy Kavitha,
  • Arumugam Rajalakshmi,
  • Balasubramanian Ramesh

摘要

Madhumukthi Kudineer Chooranum (MKC) is a decoction from polyherbal Siddha formulation for managing diabetes. The safety of this formulation has not been reported earlier. This study evaluates the chronic toxicity of the Siddha herbal formulation MKC in experimental Sprague–Dawley (SD) rats. In an acute oral toxicity study, male and female SD rats were orally administered a single dose of MKC (2000 mg/kg), and clinical signs and mortality stages were observed for 14 days along with weekly body weight. On day 15, the rats were euthanized and the gross morphology was carried out during necropsy. In a chronic (repeated dose) oral toxicity study, the male and female rats were orally administered MKC (200, 400, and 800 mg/kg) once daily for up to 180 days. MKC showed outstanding tolerance in SD rats with a NOAEL of 2000 mg/kg, with no adverse effects or death during the study. In acute and chronic toxicity trials, MKC did not alter parameters or cause harmful effects. No group died or became moribund in either study.