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<p>Extant amphibians are divided into three distinct lineages: Gymnophiona, Urodela, and Anura. Owing to their diversity, they are widely used in research concerning, among others, tissue regeneration. Here, we describe larval myotomal myogenesis in the Chinese fire-bellied newt, <i>Hypselotriton orientalis.</i> Morphological, ultrastructural, cytochemical, and immunohistochemical analyses showed that trunk muscles grow through hypertrophy and hyperplasia mediated by the expression of typical myogenic factors, such as Pax7, from muscle progenitor cells. Our findings also suggest a third alternative mechanism for muscle growth involving the muscle splitting or fragmentation of preexisting larval myotubes.</p>

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Trunk muscle differentiation—a lesson from the Chinese fire-bellied newt (Hypselotriton orientalis)

  • 期刊论文

  • 发表日期：

    2025年3月1日

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  • Magda Dubińska-Magiera,
  • Marta Julianna Brania,
  • Krzysztof Kolenda,
  • Katarzyna Haczkiewicz-Leśniak,
  • Małgorzata Daczewska,
  • Marta Migocka-Patrzałek

摘要

Extant amphibians are divided into three distinct lineages: Gymnophiona, Urodela, and Anura. Owing to their diversity, they are widely used in research concerning, among others, tissue regeneration. Here, we describe larval myotomal myogenesis in the Chinese fire-bellied newt, Hypselotriton orientalis. Morphological, ultrastructural, cytochemical, and immunohistochemical analyses showed that trunk muscles grow through hypertrophy and hyperplasia mediated by the expression of typical myogenic factors, such as Pax7, from muscle progenitor cells. Our findings also suggest a third alternative mechanism for muscle growth involving the muscle splitting or fragmentation of preexisting larval myotubes.