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<p>We present a simple and efficient method to construct sulfonyl azides from sulfonyl hydrazides using <i>N</i>-chlorosuccinimide (NCS) and trimethylsilyl azide&#xa0;(TMSN<sub>3</sub>), and <i>N</i>-sulfonyl heterocycles from readily available sulfonyl hydrazides using NCS in the presence of K<sub>2</sub>CO<sub>3</sub>. This approach is compatible with a broad range of sulfonyl hydrazides bearing various functional groups, affording good to excellent yields. The method is environmentally friendly, easy to execute, and operates under mild reaction conditions.</p> Graphical abstract <p></p>

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N-Chlorosuccinimide-mediated synthesis of sulfonyl azides and N-sulfonyl heterocycles from sulfonyl hydrazides

  • 期刊论文

  • 发表日期：

    2026年4月17日

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  • Ashvani Yadav,
  • Vikas Yadav,
  • Virendra Prasad

摘要

We present a simple and efficient method to construct sulfonyl azides from sulfonyl hydrazides using N-chlorosuccinimide (NCS) and trimethylsilyl azide (TMSN3), and N-sulfonyl heterocycles from readily available sulfonyl hydrazides using NCS in the presence of K2CO3. This approach is compatible with a broad range of sulfonyl hydrazides bearing various functional groups, affording good to excellent yields. The method is environmentally friendly, easy to execute, and operates under mild reaction conditions.

Graphical abstract