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<p>A series of ammonium salts of phenyl/(4-chlorophenyl) azosalicylic acid was synthesized. UV–Vis spectroscopy revealed characteristic absorption bands for all compounds at 260&#xa0;nm and 365&#xa0;nm. The synthesized derivatives were evaluated for in vitro biological activity against the Gram-positive bacterium <i>Staphylococcus aureus</i>, the Gram-negative bacterium <i>Pseudomonas aeruginosa</i>, and the yeast-like fungus <i>Candida utilis</i>. Additionally, their anticancer potential was assessed using human cervical adenocarcinoma (HeLa) cells and murine colon carcinoma (CT26) cell lines.</p> Graphical abstract <p></p>

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Synthesis of ammonium salts of arylazosalicylic acid, study of their optical properties, anticancer and antimicrobial activities

  • 期刊论文

  • 发表日期：

    2026年4月19日

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  • Nikolay O. Sonin,
  • Dmitry M. Egorov,
  • Irina L. Kuzikova,
  • Tatyana B. Zaytseva,
  • Zoya A. Zhakovskaya,
  • Gulia I. Bikbaeva,
  • Oussama A. Mammeri,
  • Andrey S. Drachuk,
  • Stanislav V. Shmakov,
  • Vitali M. Boitsov

摘要

A series of ammonium salts of phenyl/(4-chlorophenyl) azosalicylic acid was synthesized. UV–Vis spectroscopy revealed characteristic absorption bands for all compounds at 260 nm and 365 nm. The synthesized derivatives were evaluated for in vitro biological activity against the Gram-positive bacterium Staphylococcus aureus, the Gram-negative bacterium Pseudomonas aeruginosa, and the yeast-like fungus Candida utilis. Additionally, their anticancer potential was assessed using human cervical adenocarcinoma (HeLa) cells and murine colon carcinoma (CT26) cell lines.

Graphical abstract