First electrochemical investigation of the potent antidiabetic ertugliflozin: enhanced voltammetric detection using a boron-doped diamond electrode in CTAB-mediated measurements
摘要
The purpose of this study is to explain the voltammetric evaluation of ertugliflozin (ERTU) using the boron-doped diamond electrode with a cationic surfactant. ERTU was measured by cyclic voltammetry in 0.1 mol dm−3 HNO3 solution, revealing adsorption- and diffusion-controlled processes. The oxidation peaks were well defined at + 1.38 V (vs. Ag/AgCl). The addition of cetyltrimethylammonium bromide (CTAB, a cationic surfactant) in the selected supporting electrolyte significantly increased the oxidation peak currents of ERTU. To determine the ERTU in a solution of 0.1 mol dm−3 HNO3, the existence of the linear relationship was observed for the experimental ideal parameters, including 7.5 × 10–5 mol dm−3 CTAB at + 1.38 V (vs. Ag/AgCl) (after 30 s of accumulation in the open-circuit condition). The linear concentration range was determined by applying concentrations of 1 to 20.0 μg cm−3 (2.293 × 10–6—4.586 × 10–5 mol dm−3), with a detection limit of 0.29 μg cm−3 (6.65 × 10–7 mol dm−3). The established technology was successfully used to measure ERTU in pharmaceutical formulations and urine samples. Our research indicates that this is the first electroanalytical method for voltammetric ERTU detection to be identified.
Graphical abstract