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<p>Nowadays, the demand for greener, more sustainable methods in organic synthesis has risen. Green synthesis emphasizes the use of renewable or recyclable resources while minimizing toxic byproducts, fostering environmentally sustainable development of essential organic frameworks. A key area of interest is the green synthesis of magnetic nanoparticles (MNPs), which have gained popularity due to their unique properties and applications in green chemistry. Moreover, MNPs play a pivotal role in the synthesis of indoles, an important class of compounds in medicinal chemistry. Indoles are core structures in many biologically active molecules, including drug candidates like pindolol, oxypertine, selisistat, indomethacin, Arbidol, and sumatriptan, known for their promising pharmacological properties. Due to their versatility and potential for functionalization, indoles are highly sought after in the development of new therapeutic agents. This review covers the eco-friendly aspects of MNPs in synthesizing indole derivatives, highlighting recent advancements in creating biologically active frameworks through green synthetic methodologies.</p> Graphical abstract <p></p>

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Magnetic nanoparticle-catalyzed synthesis of indole derivatives: a green and sustainable method

  • 期刊论文

  • 发表日期：

    2025年2月23日

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  • Vaishali,
  • Shubham Sharma,
  • Ensaf Alwan,
  • Nidhi Verma,
  • Suzaimi Johari,
  • Lia Zaharani,
  • Sodeeq Aderotimi Salami,
  • Rachna,
  • Nutan Rani,
  • Swati Rani

摘要

Nowadays, the demand for greener, more sustainable methods in organic synthesis has risen. Green synthesis emphasizes the use of renewable or recyclable resources while minimizing toxic byproducts, fostering environmentally sustainable development of essential organic frameworks. A key area of interest is the green synthesis of magnetic nanoparticles (MNPs), which have gained popularity due to their unique properties and applications in green chemistry. Moreover, MNPs play a pivotal role in the synthesis of indoles, an important class of compounds in medicinal chemistry. Indoles are core structures in many biologically active molecules, including drug candidates like pindolol, oxypertine, selisistat, indomethacin, Arbidol, and sumatriptan, known for their promising pharmacological properties. Due to their versatility and potential for functionalization, indoles are highly sought after in the development of new therapeutic agents. This review covers the eco-friendly aspects of MNPs in synthesizing indole derivatives, highlighting recent advancements in creating biologically active frameworks through green synthetic methodologies.

Graphical abstract