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<p>This study introduces CuFe<sub>2</sub>O<sub>4</sub>@PDMA/Cu(II) magnetic nanoparticles (MNPs) as a novel and efficient nanocatalyst for the synthesis of dihydropyrano[3,2-<i>c</i>]chromenes, an important class of heterocyclic compounds with diverse biological activities. The catalyst, featuring a CuFe<sub>2</sub>O<sub>4</sub> core functionalized with (1,10-phenanthroline-2,9-diyl)dimethanamine (PDMA) and coordinated with copper(II) ions, facilitates the three-component reaction of aldehydes, malononitrile, and 4-hydroxycoumarin under mild conditions. This study highlights the catalyst's robust activity and magnetic properties, which enable easy recovery and reuse, aligning with the principles of green chemistry and sustainability. Enhanced reaction rates, high yields, and excellent selectivity are achieved, underscoring the potential of CuFe<sub>2</sub>O<sub>4</sub>@PDMA/Cu(II) MNPs as a versatile catalyst in the synthesis of valuable heterocyclic scaffolds. The work opens new possibilities for the application of functionalized magnetic nanoparticles in organic synthesis, offering a promising route for developing innovative catalytic processes in the production of biologically active compounds.</p> Graphical abstract <p></p>

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CuFe2O4@PDMA/Cu (II) MNPs: a novel nanomagnetic catalyst for the synthesis of dihydropyrano[3,2-c]chromenes

  • 期刊论文

  • 发表日期：

    2025年2月27日

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  • Farag M. A. Altalbawy,
  • Ali Khelif,
  • Subhash Chandra,
  • Vicky Jain,
  • Soumya V. Menon,
  • Ashish Verma,
  • Bharti Kumari

摘要

This study introduces CuFe2O4@PDMA/Cu(II) magnetic nanoparticles (MNPs) as a novel and efficient nanocatalyst for the synthesis of dihydropyrano[3,2-c]chromenes, an important class of heterocyclic compounds with diverse biological activities. The catalyst, featuring a CuFe2O4 core functionalized with (1,10-phenanthroline-2,9-diyl)dimethanamine (PDMA) and coordinated with copper(II) ions, facilitates the three-component reaction of aldehydes, malononitrile, and 4-hydroxycoumarin under mild conditions. This study highlights the catalyst's robust activity and magnetic properties, which enable easy recovery and reuse, aligning with the principles of green chemistry and sustainability. Enhanced reaction rates, high yields, and excellent selectivity are achieved, underscoring the potential of CuFe2O4@PDMA/Cu(II) MNPs as a versatile catalyst in the synthesis of valuable heterocyclic scaffolds. The work opens new possibilities for the application of functionalized magnetic nanoparticles in organic synthesis, offering a promising route for developing innovative catalytic processes in the production of biologically active compounds.

Graphical abstract