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<p>A new series of benzothiazole-oxazole derived arylethynylbenzenesulfonamides were designed and synthesised, and their chemical structures were validated using spectroscopic methods. The compounds were further tested for anticancer activity against human cell lines such as prostate cancer (PC3 and DU-145), lung cancer (A549), and breast cancer (MCF-7) using the MTT assay with the anticancer drug etoposide as a positive control. All of the studied substances showed promising anticancer properties.</p> Graphical abstract <p></p>

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Design and synthesis of some new benzothiazole-oxazole derived arylethynylbenzenesulfonamides for possible anticancer agents

  • 期刊论文

  • 发表日期：

    2025年2月23日

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  • Hari Babu Bollikolla,
  • Gangadhara Rao Mannem,
  • Ramesh Navudu,
  • Bala Murali Krishna Khandapu,
  • Baby Ramana Mutchu,
  • Ravi Varala

摘要

A new series of benzothiazole-oxazole derived arylethynylbenzenesulfonamides were designed and synthesised, and their chemical structures were validated using spectroscopic methods. The compounds were further tested for anticancer activity against human cell lines such as prostate cancer (PC3 and DU-145), lung cancer (A549), and breast cancer (MCF-7) using the MTT assay with the anticancer drug etoposide as a positive control. All of the studied substances showed promising anticancer properties.

Graphical abstract