Starch-supported cuprous iodide nanoparticles catalysed C–C bond cleavage: use of carbon-based leaving groups for bisindolylmethane synthesis
摘要
A starch-supported cuprous iodide nanoparticles (CuI-NPs@starch) catalysed C–C bond cleaving reaction involving carbon-based leaving groups like malononitrile, ethyl cyanoacetate, acetylacetone, and Meldrum’s acid has been developed under moisture and air insensitive conditions. This competent C–C bond cleavage reaction is studied in detail as an attractive alternative method to synthesize biologically relevant bisindolylmethanes in moderate to good yields. The CuI-NPs@starch are synthesized in aqueous medium and characterized by X-ray powder diffraction, scanning electron microscopy, energy-dispersive X-ray spectroscopy studies.
Graphical abstract