Scholarlink

<p>Neddylation, a conserved ubiquitin-like modification, critically regulates viral pathogenesis and host immunity. This review synthesizes recent advances demonstrating how viruses exploit host neddylation to enhance replication—either by direct neddylation of viral proteins or by subverting cullin-RING ligases (CRLs) to degrade antiviral restriction factors. Conversely, neddylation bolsters innate immunity by activating Interferon Regulatory Factor 7 (IRF7) nuclear translocation, potentiating cylic GMP-AMP synthase -Stimulator of Interferon Genes ༈cGAS-STING༉ signaling, and regulating inflammasome-dependent cytokine responses. The NEDD8 activating enzyme E1 subunit 1(NAE1) inhibitor MLN4924 exhibits broad antiviral activity against herpesviruses, influenza, Human Immunodeficiency Virus, and coronaviruses. Understanding neddylation’s dual roles - as a proviral facilitator and immune modulator - provides novel insights for antiviral strategies.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Viral subversion of neddylation: dual roles in replication efficiency and evasion of antiviral immunity

  • 期刊论文

  • 发表日期：

    2026年3月19日

查看全文
  • Xiaoli Mo,
  • Bohan Yu,
  • Xudong Tang

摘要

Neddylation, a conserved ubiquitin-like modification, critically regulates viral pathogenesis and host immunity. This review synthesizes recent advances demonstrating how viruses exploit host neddylation to enhance replication—either by direct neddylation of viral proteins or by subverting cullin-RING ligases (CRLs) to degrade antiviral restriction factors. Conversely, neddylation bolsters innate immunity by activating Interferon Regulatory Factor 7 (IRF7) nuclear translocation, potentiating cylic GMP-AMP synthase -Stimulator of Interferon Genes ༈cGAS-STING༉ signaling, and regulating inflammasome-dependent cytokine responses. The NEDD8 activating enzyme E1 subunit 1(NAE1) inhibitor MLN4924 exhibits broad antiviral activity against herpesviruses, influenza, Human Immunodeficiency Virus, and coronaviruses. Understanding neddylation’s dual roles - as a proviral facilitator and immune modulator - provides novel insights for antiviral strategies.