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<p>Coxsackievirus A10 (CV-A10) has become an important cause of hand, foot, and mouth disease (HFMD). Molecular surveillance in northern Vietnam during 2018–2020 revealed the introduction and rapid dominance of the genotype C lineage (CHN), replacing the previously endemic lineage (VNM). This shift was associated with a significant increase in detection and altered clinical severity, predominantly grade 2A (83.8%). Phylogenetic analysis revealed the close relatedness between the emerging Vietnamese strains and those circulating in China (2017–2024). These findings suggest lineage-dependent virulence in CV-A10, highlighting the need for lineage-level molecular surveillance to guide HFMD control and vaccine development.</p>

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Lineage replacement of coxsackievirus A10 in Vietnam associated with increased detection and altered disease severity grading of hand, foot, and mouth disease

  • 期刊论文

  • 发表日期：

    2026年2月24日

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  • Anh The Nguyen,
  • Hong Thi Thu Ta,
  • Anh Thi Hai Dao,
  • Hung Manh Vu,
  • Nghia Duy Ngu,
  • Duong Nhu Tran,
  • Hiroyuki Shimizu,
  • Yorihiro Nishimura,
  • Thi Nguyen Hoa-Tran

摘要

Coxsackievirus A10 (CV-A10) has become an important cause of hand, foot, and mouth disease (HFMD). Molecular surveillance in northern Vietnam during 2018–2020 revealed the introduction and rapid dominance of the genotype C lineage (CHN), replacing the previously endemic lineage (VNM). This shift was associated with a significant increase in detection and altered clinical severity, predominantly grade 2A (83.8%). Phylogenetic analysis revealed the close relatedness between the emerging Vietnamese strains and those circulating in China (2017–2024). These findings suggest lineage-dependent virulence in CV-A10, highlighting the need for lineage-level molecular surveillance to guide HFMD control and vaccine development.