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<p>Multidrug-resistant <i>Klebsiella pneumoniae</i> requires alternative therapies. In this study, we characterized two novel phages, PKP K9 (a siphovirus) and PKP Kh11 (a myovirus). Both showed genomic safety and exhibited excellent reproduction and physicochemical tolerance. A cocktail containing both phages had a broad combined host range (85.7%, 72/84) and showed potent <i>in vitro</i> activity with distinct dose-dependent inhibition modes. In a <i>Galleria mellonella</i> infection model, each phage individually and the two combined provided complete prophylactic and therapeutic protection against lethal challenge. The PKP K9/PKP Kh11 cocktail demonstrates significant therapeutic potential against multidrug-resistant <i>K. pneumoniae</i>.</p>

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Phage-cocktail-based biocontrol of multidrug-resistant Klebsiella pneumoniae both in vitro and in vivo

  • 期刊论文

  • 发表日期：

    2026年1月11日

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  • Ling Zou,
  • Yang Yu,
  • Dongxue Yue,
  • Chuanxu Wang,
  • Shijie Xu,
  • Wenhua Liu,
  • Shouzhen Xu,
  • Jing Ma,
  • Hong-Bo Ni,
  • Tao He,
  • Ran Wang,
  • Yehui Sun,
  • Can Zhang

摘要

Multidrug-resistant Klebsiella pneumoniae requires alternative therapies. In this study, we characterized two novel phages, PKP K9 (a siphovirus) and PKP Kh11 (a myovirus). Both showed genomic safety and exhibited excellent reproduction and physicochemical tolerance. A cocktail containing both phages had a broad combined host range (85.7%, 72/84) and showed potent in vitro activity with distinct dose-dependent inhibition modes. In a Galleria mellonella infection model, each phage individually and the two combined provided complete prophylactic and therapeutic protection against lethal challenge. The PKP K9/PKP Kh11 cocktail demonstrates significant therapeutic potential against multidrug-resistant K. pneumoniae.