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<p>Equid alphaherpesvirus type 1 (EHV-1) is a neurotropic virus known to manipulate host cytoskeletal structures to facilitate infection and spread. In this study, we examined the susceptibility of primary murine astrocytes to neuropathogenic and non-neuropathogenic EHV-1 strains, focusing on the role of the actin and microtubule cytoskeleton. Infection induces morphological changes and remodeling of actin and microtubule networks. Viral antigen was localized along actin filaments and microtubules, indicating their likely role in intracellular viral trafficking. Cytoskeletal inhibitors significantly reduced viral DNA levels. Both EHV-1 strains exhibited limited replication, suggesting that EHV-1 may establish abortive infection in murine astrocytes.</p>

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Equid alphaherpesvirus 1 (EHV-1) infection of primary murine astrocytes: role of the cytoskeleton

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年12月11日

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  • Anna Słońska,
  • Joanna Cymerys

摘要

Equid alphaherpesvirus type 1 (EHV-1) is a neurotropic virus known to manipulate host cytoskeletal structures to facilitate infection and spread. In this study, we examined the susceptibility of primary murine astrocytes to neuropathogenic and non-neuropathogenic EHV-1 strains, focusing on the role of the actin and microtubule cytoskeleton. Infection induces morphological changes and remodeling of actin and microtubule networks. Viral antigen was localized along actin filaments and microtubules, indicating their likely role in intracellular viral trafficking. Cytoskeletal inhibitors significantly reduced viral DNA levels. Both EHV-1 strains exhibited limited replication, suggesting that EHV-1 may establish abortive infection in murine astrocytes.