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<p><i>Bl</i>D-PLA<sub>2</sub>, a phospholipase A₂ isolated from <i>Bothrops leucurus</i> venom, exhibited notable antiviral activity against dengue virus (DENV) <i>in vitro</i>. Treatment significantly reduced viral RNA levels, particularly when administered during the infection period, suggesting interference with early stages of viral entry. Immunofluorescence and ELISA assays confirmed its interaction with host cell components. Importantly, reseeding assays demonstrated that residual viral RNA detected after treatment was not associated with infectious particles. These findings indicate that <i>Bl</i>D-PLA<sub>2</sub> effectively disrupts DENV infection and support its potential as a lead compound for the development of novel antiviral strategies.&#xa0;</p>

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Therapeutic potential of Bothrops leucurus phospholipase A2 in preventing dengue virus infection

  • 期刊论文

  • 发表日期：

    2025年11月10日

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  • Sérgio Caldas,
  • Gilson Faria,
  • Fernanda de Oliveira Silva,
  • Ana Caroline Zampiroli Ataide,
  • Luciene Silva de Souza Meira,
  • Valeria Gonçalves de Alvarenga,
  • Luciana Souza de Oliveira,
  • Eladio Flores Sanchez

摘要

BlD-PLA2, a phospholipase A₂ isolated from Bothrops leucurus venom, exhibited notable antiviral activity against dengue virus (DENV) in vitro. Treatment significantly reduced viral RNA levels, particularly when administered during the infection period, suggesting interference with early stages of viral entry. Immunofluorescence and ELISA assays confirmed its interaction with host cell components. Importantly, reseeding assays demonstrated that residual viral RNA detected after treatment was not associated with infectious particles. These findings indicate that BlD-PLA2 effectively disrupts DENV infection and support its potential as a lead compound for the development of novel antiviral strategies.