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<p>Epizootic hemorrhagic disease virus (EHDV) causes severe disease in ruminants. We assessed the pathogenicity of the Chinese EHDV-7 isolate YN09 in mice lacking the type I interferon receptor and in sheep. In mice, YN09 infection resulted in 100% mortality, with histopathological lesions, viral replication, and immunoreactivity in multiple organs. In sheep, infection with this virus resulted in transient RNAemia and low-level production of neutralizing antibodies, but no clinical signs or viremia were observed. These findings contrast YN09’s high murine virulence with sheep resistance, suggesting that sheep play a negligible role in EHDV-7 transmission in China. Further studies of other natural hosts are needed in order to understand the ecology of this EHDV-7 strain.&#xa0;</p>

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Contrasting pathogenicity of an epizootic hemorrhagic disease virus serotype 7 isolate: high virulence in IFNAR(-/-) mice versus a negligible role of sheep in EHDV-7 epidemiology

  • 期刊论文

  • 发表日期：

    2025年9月11日

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  • Junyong Guan,
  • Yinglin Qi,
  • Yingran Huang,
  • Ran Shao,
  • Dong Zhou,
  • Cankun Xi,
  • Xin Yin

摘要

Epizootic hemorrhagic disease virus (EHDV) causes severe disease in ruminants. We assessed the pathogenicity of the Chinese EHDV-7 isolate YN09 in mice lacking the type I interferon receptor and in sheep. In mice, YN09 infection resulted in 100% mortality, with histopathological lesions, viral replication, and immunoreactivity in multiple organs. In sheep, infection with this virus resulted in transient RNAemia and low-level production of neutralizing antibodies, but no clinical signs or viremia were observed. These findings contrast YN09’s high murine virulence with sheep resistance, suggesting that sheep play a negligible role in EHDV-7 transmission in China. Further studies of other natural hosts are needed in order to understand the ecology of this EHDV-7 strain.