<p>Extreme temperature events directly and significantly influence human comfort (HC) in China more than the average. Therefore, this study is based on the daily maximum/minimum observed temperatures, wind speed, and relative humidity from 1,656 meteorological stations in China between 1960-2019, analyzing the significance, sensitivity, and causes of extreme apparent temperature (AT) trends in China, followed by the changes in HC under different climate regimes in the new (1990-2019) and old (1960-1989). The results show that AT has a significant upward trend, with noticeable spatiotemporal differences in the significance of AT trends and the contribution rates of meteorological factors to AT. HC became hot discomfort has become a trend, in which the increase in the intensity of extreme heat discomfort in summer was obvious. However, the number of days of extreme cold discomfort of the minimum AT in northern winter increased. Extreme thermal discomfort also increased from none in spring and fall in the Tibetan Plateau and Northwest China. The frequency of warm nights in summer in southern China has increased significantly, and there has been a phenomenon of hot nights. Overall, alterations in comfort are concentrated within the plain regions and climatic transition zones. HC becomes comfortable in the northern maximum AT in spring and fall and uncomfortable in the south. The nighttime comfort level in the southern North China Plain has become uncomfortable in summer. This study can enrich the knowledge of HC intensity and grade changes at extreme temperatures.</p> Graphical Abstract <p></p>