<p>Wind energy remains unexplored in the eastern parts of India, specifically in Odisha. Monsoon low-pressure systems, such as deep depressions (DD) forming over the Bay of Bengal (BoB) act as lifelines of the monsoon. DD are crucial to the Indian monsoon and capable of generating strong winds, yet their potential as a renewable energy resource remains underexplored. The present study evaluates constrained wind power density (WPD) at a hub height of 100 m across Odisha’s four meteorological zones and districts, aiming to identify favourable sites for future wind energy projects. A multi-physics ensemble (MPE) approach using 72 hour simulations from the Weather Research and Forecasting (WRF) model and European Centre for Medium-Range Weather Forecasts Reanalysis Version 5 (ERA5) is employed for seven monsoon DD events occurring between 2006 and 2017. Results show a distinct WPD peak during the 25–48 hour simulation period, with values reaching up to 4500 W/m² in the South Interior Odisha (SIO) zone and declining to 600 W/m² during 49–72 hour. Districts of Nuapada, Nabarangpur, and Gajapati exceed 500 W/m² indicating strong wind energy potential (WEP). Diurnal analysis reveals daytime dominance of WPD, though night-time enhancement is evident in northern interior and north coastal Odisha districts. These findings highlight wind energy’s advantage, providing a more reliable energy supply at all times, and portrays the spatial diversity and reliability of wind energy resources in Odisha, establishing southern meteorological zones (SIO and SCO) as prime regions for future wind farm development and renewable energy investment.</p>