Scholarlink

<p>In Parkinson’s disease (PD), neuronal loss occurs in the substantia nigra (SN) and locus coeruleus (LC). Previous studies using neuromelanin-sensitive magnetic resonance imaging (NMI) at 3T MRI have described the measurement methods and diagnostic significance of the contrast ratio (SN-CR) and area (SN-A), as well as their association with clinical symptoms. However, no reports have evaluated the consistency of NMIs acquired using different MR protocols in the same patients over a short period. Therefore, this study evaluated the similarity of two-dimensional (2D) NMIs obtained simultaneously under different imaging parameters. The SN-CR, LC-CR, and SN-A were compared in 54 of 55 patients with PD who underwent 2D NMIs within 3 months under different imaging conditions, with one patient excluded due to artifacts. The relationships of these variables with motor and cognitive function were then examined. The mean age of the cohort was 62.3 ± 8.0 years. The mean disease duration was 11.4 ± 5.2 years, and the male-to-female ratio was 25:29. No significant correlation was found for SN-CR (<i>r</i> = 0.233, <i>p</i> = 0.091) and LC-CR (ρ = 0.180, <i>p</i> = 0.192). However, a significant, albeit weak, positive correlation was observed for SN-A (ρ = 0.403, <i>p</i> = 0.003). Standardization of imaging protocols is essential to minimize technical variability.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Comparison of neuromelanin-sensitive magnetic resonance imaging using different magnetic resonance protocols on the same patients with Parkinson’s disease

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年5月26日

查看全文
  • Rinka Hirose,
  • Keita Matsuura,
  • Yuichiro Ii,
  • Hiroyuki Kajikawa,
  • Masayuki Maeda,
  • Maki Umino,
  • Ken-ichi Tabei,
  • Akisato Nishigaki,
  • Shotaro Horie,
  • Hidehiro Ishikawa,
  • Ken Kagawa,
  • Akihiro Shindo

摘要

In Parkinson’s disease (PD), neuronal loss occurs in the substantia nigra (SN) and locus coeruleus (LC). Previous studies using neuromelanin-sensitive magnetic resonance imaging (NMI) at 3T MRI have described the measurement methods and diagnostic significance of the contrast ratio (SN-CR) and area (SN-A), as well as their association with clinical symptoms. However, no reports have evaluated the consistency of NMIs acquired using different MR protocols in the same patients over a short period. Therefore, this study evaluated the similarity of two-dimensional (2D) NMIs obtained simultaneously under different imaging parameters. The SN-CR, LC-CR, and SN-A were compared in 54 of 55 patients with PD who underwent 2D NMIs within 3 months under different imaging conditions, with one patient excluded due to artifacts. The relationships of these variables with motor and cognitive function were then examined. The mean age of the cohort was 62.3 ± 8.0 years. The mean disease duration was 11.4 ± 5.2 years, and the male-to-female ratio was 25:29. No significant correlation was found for SN-CR (r = 0.233, p = 0.091) and LC-CR (ρ = 0.180, p = 0.192). However, a significant, albeit weak, positive correlation was observed for SN-A (ρ = 0.403, p = 0.003). Standardization of imaging protocols is essential to minimize technical variability.