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<p>Parkinson’s disease (PD) is a progressive neurodegenerative disorder with a wide variety of symptoms and evolution. In addition, the response to antiparkinsonian medication is not predictable, especially for those patients with advanced PD. Pharmacogenetics and pharmacogenomics may help to decide the best available treatment based on the genetic background of the patients. This approach has been already used in Oncology leading to personalized pharmacology. In this article, we review and comment the updated information regarding pharmacogenetics and pharmacogenomics applied to PD.</p>

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Pharmacogenetics in advanced Parkinson’s disease

  • 期刊论文

  • 发表日期：

    2025年11月12日

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  • Jaime Kulisevsky,
  • Pedro García-Ruíz,
  • Tiago Fleming Outeiro,
  • Tanya Gurevich,
  • Péter Klivènyi,
  • Teus Van Laar,
  • Ivan Milanov,
  • Walter Pirker,
  • Bogdan O. Popescu,
  • Mathias Toft,
  • József Attila Szász

摘要

Parkinson’s disease (PD) is a progressive neurodegenerative disorder with a wide variety of symptoms and evolution. In addition, the response to antiparkinsonian medication is not predictable, especially for those patients with advanced PD. Pharmacogenetics and pharmacogenomics may help to decide the best available treatment based on the genetic background of the patients. This approach has been already used in Oncology leading to personalized pharmacology. In this article, we review and comment the updated information regarding pharmacogenetics and pharmacogenomics applied to PD.