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<p>Alcohol withdrawal syndrome is increasingly recognized as a significant public health concern in India and worldwide, highlighting the pressing need for innovative therapeutic strategies. The Sigma-1 receptor system has recently garnered attention as a potential target in the treatment of Alcohol withdrawal syndrome. Evidence from preclinical animal studies indicates that Sigma-1 receptor antagonists can effectively reduce alcohol intake, diminish the motivation to drink, and inhibit alcohol-seeking behaviors. They also show potential in addressing cognitive deficits, motor function disruptions, and relapse-like behaviors. These findings suggest a pivotal role of Sigma-1 receptor in modulating addiction-related mechanisms. Although current FDA-approved treatments such as disulfiram, naltrexone, and acamprosate offer some clinical benefits, the underlying pathways through which Sigma-1 receptor influences alcohol dependence are not yet fully elucidated. Continued research into Sigma-1 receptor -mediated mechanisms may not only enhance our neurobiological understanding of Alcohol Used Disorder and Alcohol Withdrawal Syndrome but also support the development of more precise and effective treatment options.</p>

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Alcohol withdrawal and the sigma receptor: exploring the link between withdrawal and cognitive impairment

  • 期刊论文

  • 发表日期：

    2025年10月15日

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  • Ajay V. Lokhande,
  • Smeeta S . Sadar,
  • Niraj S. Vyawahare,
  • Pavankumar P. Wankhade,
  • Gauri P. Gawande

摘要

Alcohol withdrawal syndrome is increasingly recognized as a significant public health concern in India and worldwide, highlighting the pressing need for innovative therapeutic strategies. The Sigma-1 receptor system has recently garnered attention as a potential target in the treatment of Alcohol withdrawal syndrome. Evidence from preclinical animal studies indicates that Sigma-1 receptor antagonists can effectively reduce alcohol intake, diminish the motivation to drink, and inhibit alcohol-seeking behaviors. They also show potential in addressing cognitive deficits, motor function disruptions, and relapse-like behaviors. These findings suggest a pivotal role of Sigma-1 receptor in modulating addiction-related mechanisms. Although current FDA-approved treatments such as disulfiram, naltrexone, and acamprosate offer some clinical benefits, the underlying pathways through which Sigma-1 receptor influences alcohol dependence are not yet fully elucidated. Continued research into Sigma-1 receptor -mediated mechanisms may not only enhance our neurobiological understanding of Alcohol Used Disorder and Alcohol Withdrawal Syndrome but also support the development of more precise and effective treatment options.