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Background <p>Idiopathic Normal Pressure Hydrocephalus (iNPH) remains a challenging clinical diagnosis with variable treatment response.</p> Objectives <p>This study aimed to identify clinical, imaging, and CSF biomarkers associated with favorable outcomes following shunt placement.</p> Methods <p>All patients evaluated for iNPH at the Tel-Aviv Medical Center (TLVMC) between 2020 and 2022 were included. Participants underwent clinical, cognitive, and imaging assessments, high-volume lumbar puncture (LP). LP responders were referred for shunt placement, and outcomes assessed at one year.</p> Results <p>183 patients were evaluated; 167 met criteria for suspected iNPH and underwent LP. Sixty-two (37%) patients showed improvement after CSF drainage and were referred for shunting. Of these, 38 (61%) underwent shunt placement. Gait disturbance was the most common presenting symptom (68%), and more frequent in LP responders (<i>p</i> = 0.007), whereas cognitive symptoms were more common among non-responders (29.5% vs. 10%). LP responders had lower CSF total tau (t-tau) (222.6 ± 99.1 vs. 256 ± 107.1, <i>p</i> = 0.045) and protein (41.1 ± 17.1 vs. 49.1 ± 25.7, <i>p</i> = 0.032) and were more likely to exhibit a disproportionately enlarged subarachnoid-space hydrocephalus (DESH) pattern (73% vs. 46%, <i>p</i> &lt; 0.001). Among the 38 shunted patients, 21 (55%) had a favourable outcome at one year, which was associated with lower t-tau (<i>p</i> = 0.056) and more frequent DESH (<i>p</i> = 0.026).</p> Conclusions <p>Over half of patients who underwent shunt placement experienced favorable clinical outcomes at one year. Lower t-tau and DESH pattern were associated with better outcomes.</p>

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Predictors of shunt responsiveness and outcomes in idiopathic normal pressure hydrocephalus: a retrospective cohort study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年3月23日

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  • Dror Shir,
  • Noa Bregman,
  • Jonathan Roth,
  • Elissa Ash,
  • Tamara Shiner

摘要

Background

Idiopathic Normal Pressure Hydrocephalus (iNPH) remains a challenging clinical diagnosis with variable treatment response.

Objectives

This study aimed to identify clinical, imaging, and CSF biomarkers associated with favorable outcomes following shunt placement.

Methods

All patients evaluated for iNPH at the Tel-Aviv Medical Center (TLVMC) between 2020 and 2022 were included. Participants underwent clinical, cognitive, and imaging assessments, high-volume lumbar puncture (LP). LP responders were referred for shunt placement, and outcomes assessed at one year.

Results

183 patients were evaluated; 167 met criteria for suspected iNPH and underwent LP. Sixty-two (37%) patients showed improvement after CSF drainage and were referred for shunting. Of these, 38 (61%) underwent shunt placement. Gait disturbance was the most common presenting symptom (68%), and more frequent in LP responders (p = 0.007), whereas cognitive symptoms were more common among non-responders (29.5% vs. 10%). LP responders had lower CSF total tau (t-tau) (222.6 ± 99.1 vs. 256 ± 107.1, p = 0.045) and protein (41.1 ± 17.1 vs. 49.1 ± 25.7, p = 0.032) and were more likely to exhibit a disproportionately enlarged subarachnoid-space hydrocephalus (DESH) pattern (73% vs. 46%, p < 0.001). Among the 38 shunted patients, 21 (55%) had a favourable outcome at one year, which was associated with lower t-tau (p = 0.056) and more frequent DESH (p = 0.026).

Conclusions

Over half of patients who underwent shunt placement experienced favorable clinical outcomes at one year. Lower t-tau and DESH pattern were associated with better outcomes.