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Background <p>Subacute sclerosing panencephalitis (SSPE) is a chronic disease affecting the central nervous system (CNS) because of persistent measles virus (MeV) infection. Among the various treatment available the intraventricular interferon alpha administration demonstrated greater effectiveness.</p> Method <p>In this article is described the step-by-step surgical technique of the positioning of an intraventricular catheter connected to a rechargeable subcutaneous pump. The main surgical steps and the pump settings are illustrated in a supplementary video.</p> Conclusion <p>This surgical management guarantees a continuous drug release improving the therapeutic effect in terms of clinical and neuroradiological outcome and reducing the toxicity profile.</p>

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How I do it: continuous intraventricular interferon alpha infusion in pediatric patients with subacute sclerosing panencephalitis

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年11月8日

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  • Francesco Tengattini,
  • Gabriella Errichiello,
  • Antonio Varone,
  • Giuseppe Cinalli,
  • Claudio Ruggiero

摘要

Background

Subacute sclerosing panencephalitis (SSPE) is a chronic disease affecting the central nervous system (CNS) because of persistent measles virus (MeV) infection. Among the various treatment available the intraventricular interferon alpha administration demonstrated greater effectiveness.

Method

In this article is described the step-by-step surgical technique of the positioning of an intraventricular catheter connected to a rechargeable subcutaneous pump. The main surgical steps and the pump settings are illustrated in a supplementary video.

Conclusion

This surgical management guarantees a continuous drug release improving the therapeutic effect in terms of clinical and neuroradiological outcome and reducing the toxicity profile.