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Background <p>For drug-resistant mesial temporal lobe epilepsy (MTLE), surgery is recommended. There is no evidence of a seizure outcome advantage of temporal lobectomy over other strategies despite the high risks of this surgical procedure.</p> Methods <p>We describe a Temporal Resection guided by intraoperative stereo-electroencephalography (iSEEG) and the <sup>18</sup>FluoroDeoxyGlucose PET (<sup>18</sup>FDG PET) (iSP-TR) to treat lesional MTLE. We avoided functional cortical areas using navigated Transcranial Magnetic Stimulation (nTMS).</p> Conclusion <p>iSP-TR allows for a spare brain parenchyma compared to temporal lobectomy without compromising seizure outcomes.</p>

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The intraoperative SEEG and 18FDG-PET tailored temporal lobe resection (iSP-TR) for the tissue-spearing surgical treatment of drug-resistant mesial temporal lobe epilepsy: how we do it

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  • 发表日期：

    2025年3月19日

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  • Francesca Battista,
  • Riccardo Carrai,
  • Antonello Grippo,
  • Alessandro Della Puppa

摘要

Background

For drug-resistant mesial temporal lobe epilepsy (MTLE), surgery is recommended. There is no evidence of a seizure outcome advantage of temporal lobectomy over other strategies despite the high risks of this surgical procedure.

Methods

We describe a Temporal Resection guided by intraoperative stereo-electroencephalography (iSEEG) and the 18FluoroDeoxyGlucose PET (18FDG PET) (iSP-TR) to treat lesional MTLE. We avoided functional cortical areas using navigated Transcranial Magnetic Stimulation (nTMS).

Conclusion

iSP-TR allows for a spare brain parenchyma compared to temporal lobectomy without compromising seizure outcomes.