Scholarlink

<p>Heavy metal pollution poses severe threats to environmental safety and human health, driving the demand for highly sensitive and selective detection technologies. Metal-organic framework (MOF)-based nanozymes have emerged as promising sensing platforms due to their tunable structures, high surface areas, and enzyme-mimicking activities. By integrating dual-signal outputs—such as colorimetric/fluorescence, colorimetric/electrochemical, or electrochemiluminescence/colorimetric-these sensors enable cross-validated detection with enhanced reliability, anti-interference capability, and adaptability to complex matrices. This review systematically summarizes recent advances in MOF nanozyme design and their application in dual-mode sensing of heavy metal ions (e.g., Hg<sup>2+</sup>, Pb<sup>2+</sup>, Cu<sup>2+</sup>, Cr<sup>6+</sup>). We first classify MOF nanozymes into pristine and composite types, discussing their catalytic origins and structure-activity relationships. Next, we elaborate on the construction strategies of dual-mode sensors, focusing on band engineering, interfacial electron transfer, synergistic recognition, and nanoconfinement effects. Representative applications are critically reviewed, highlighting detection mechanisms, performance parameters, and real-sample applicability. Finally, we outline current challenges and future directions, including the development of biomimetic recognition, multiplexed detection, miniaturized platforms, and green synthesis. This work aims to provide a comprehensive reference for designing next-generation MOF nanozyme sensors for environmental monitoring and biosensing.</p> Graphical Abstract <p></p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Metal-organic framework nanozymes for dual-mode sensing of heavy metal ions: design strategies, mechanisms, and applications

  • 期刊论文

  • 发表日期：

    2026年8月1日

查看全文
  • Xiuhong Ge,
  • Dongxue Liu,
  • Hongkun Lin,
  • Dengming Zhao,
  • Jing Dong,
  • Hui Zhang,
  • Ping Zhang,
  • Chen Li,
  • Shanshan An,
  • Fei Ren,
  • Lang Cheng,
  • Feiyan Yang,
  • Jiahan Liu,
  • Jiabo Fu,
  • Furui Tang,
  • Feifei Wang,
  • Tianzi Liu,
  • Hongzhi Pan,
  • Shengzhong Rong,
  • Hongkun Ma,
  • Lina Zou

摘要

Heavy metal pollution poses severe threats to environmental safety and human health, driving the demand for highly sensitive and selective detection technologies. Metal-organic framework (MOF)-based nanozymes have emerged as promising sensing platforms due to their tunable structures, high surface areas, and enzyme-mimicking activities. By integrating dual-signal outputs—such as colorimetric/fluorescence, colorimetric/electrochemical, or electrochemiluminescence/colorimetric-these sensors enable cross-validated detection with enhanced reliability, anti-interference capability, and adaptability to complex matrices. This review systematically summarizes recent advances in MOF nanozyme design and their application in dual-mode sensing of heavy metal ions (e.g., Hg2+, Pb2+, Cu2+, Cr6+). We first classify MOF nanozymes into pristine and composite types, discussing their catalytic origins and structure-activity relationships. Next, we elaborate on the construction strategies of dual-mode sensors, focusing on band engineering, interfacial electron transfer, synergistic recognition, and nanoconfinement effects. Representative applications are critically reviewed, highlighting detection mechanisms, performance parameters, and real-sample applicability. Finally, we outline current challenges and future directions, including the development of biomimetic recognition, multiplexed detection, miniaturized platforms, and green synthesis. This work aims to provide a comprehensive reference for designing next-generation MOF nanozyme sensors for environmental monitoring and biosensing.

Graphical Abstract