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<p> A novel two-dimensional metal-organic framework (2D MOF), 2D Co-MOF@MnO<sub>2</sub>, with oxidase-like activity was successfully prepared via a solvothermal method, and its mimetic oxidase-like activity was investigated in detail. Its kinetic parameters <i>K</i><sub><i>m</i></sub> and <i>V</i><sub><i>max</i></sub> were determined to be 0.048 mM and 5.897 × 10<sup>− 7</sup> Ms<sup>− 1</sup>, respectively. Taking advantage of the material’s ability to catalyze the oxidation of 3,3’,5,5’-tetramethylbenzidine (TMB) and the inhibitory effect of uric acid (UA) on this oxidase-like activity, we designed and constructed a portable colorimetric sensing device for the rapid detection of UA. This device enabled UA detection within 3&#xa0;min at room temperature. The proposed system showed a linear response in the concentration range 5-200 µM with a detection limit of 4.98 µM, which was comparable to or even better than several previously reported colorimetric methods. This proof-of-concept study presented a novel and efficient approach that had potential for future point-of-care (POCT) applications for uric acid detection, and may offer new insights into early disease diagnosis, health monitoring, and biomedical research.</p> Graphical abstract <p></p>

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A novel 2D Co-MOF@MnO2 composite material with enhanced oxidase-like activity for rapid uric acid detection and portable sensor device development

  • 期刊论文

  • 发表日期：

    2026年6月18日

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  • Yun Zhu,
  • Tianshu Luo,
  • Jingge Niu,
  • Jie Cao,
  • Yizhuo Pang,
  • Xiaohong Hou

摘要

A novel two-dimensional metal-organic framework (2D MOF), 2D Co-MOF@MnO2, with oxidase-like activity was successfully prepared via a solvothermal method, and its mimetic oxidase-like activity was investigated in detail. Its kinetic parameters Km and Vmax were determined to be 0.048 mM and 5.897 × 10− 7 Ms− 1, respectively. Taking advantage of the material’s ability to catalyze the oxidation of 3,3’,5,5’-tetramethylbenzidine (TMB) and the inhibitory effect of uric acid (UA) on this oxidase-like activity, we designed and constructed a portable colorimetric sensing device for the rapid detection of UA. This device enabled UA detection within 3 min at room temperature. The proposed system showed a linear response in the concentration range 5-200 µM with a detection limit of 4.98 µM, which was comparable to or even better than several previously reported colorimetric methods. This proof-of-concept study presented a novel and efficient approach that had potential for future point-of-care (POCT) applications for uric acid detection, and may offer new insights into early disease diagnosis, health monitoring, and biomedical research.

Graphical abstract