<p>Binary metal-organic framework embellished magnetic black phosphorus nanosheets (Fe₃O₄/BPNSs/Ce-Zr MOF) were successfully prepared. This synthesis strategy avoided the traditional reliance on chelating agents and simplified the synthesis process. The physicochemical properties of Fe₃O₄/BPNSs/Ce-Zr MOF were systematically characterized by various means, such as transmission electron microscopy and X-ray diffraction analysis. The prepared material exhibited a high surface area, good hydrophilicity, and rapid magnetic responsiveness. Fe₃O₄/BPNSs/Ce-Zr MOF showed good affinity, which allowed the efficient capture of phosphopeptides from complex samples containing 5000-fold interfering peptides. Furthermore, Fe₃O₄/BPNSs/Ce-Zr MOF was applied to enrich phosphopeptides from more complicated biosamples, such as A549 cell lysate, highlighting its potential in phosphoproteomics applications.</p> Graphical abstract <p></p>