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<p>Hepatic fibrosis, driven by hepatic stellate cell (HSC) activation and excessive extracellular matrix (ECM) deposition, is closely associated with iron overload. To enable simultaneous diagnosis and treatment, a multifunctional hydrogel nanocomposite (SA-1@MG) was developed by modifying sodium alginate with a compound 1-based Fe³⁺-responsive fluorophore and loading mangiferin (MG). SA-1@MG exhibited strong, selective fluorescence quenching toward Fe³⁺ (R² = 0.9992) and high stability under physiological conditions. In vitro studies using TGF-β1-induced LX-2 cells confirmed that SA-1@MG effectively suppressed fibrotic markers (ACTA2, COL1A1, TIMP1, TGFB1), demonstrating enhanced antifibrotic activity compared to free MG. These results highlight SA-1@MG as a dual-functional platform for Fe³⁺ fluorescence detection and hepatic fibrosis therapy, providing a promising strategy for early diagnosis and treatment of liver fibrosis.</p> Graphical Abstract <p></p>

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Biofunctional alginate hydrogel enabling Fe³⁺ detection and therapeutic modulation of hepatic fibrosis

  • 期刊论文

  • 发表日期：

    2026年3月9日

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  • Jiaxing Li,
  • Qiao Li,
  • Zhongqi Huang,
  • Yongsong Huang,
  • Rongqi Wang,
  • Jiazhu Wei,
  • Ze Wang,
  • Junxia Pu,
  • Chengtong Liu,
  • Wujun Wei

摘要

Hepatic fibrosis, driven by hepatic stellate cell (HSC) activation and excessive extracellular matrix (ECM) deposition, is closely associated with iron overload. To enable simultaneous diagnosis and treatment, a multifunctional hydrogel nanocomposite (SA-1@MG) was developed by modifying sodium alginate with a compound 1-based Fe³⁺-responsive fluorophore and loading mangiferin (MG). SA-1@MG exhibited strong, selective fluorescence quenching toward Fe³⁺ (R² = 0.9992) and high stability under physiological conditions. In vitro studies using TGF-β1-induced LX-2 cells confirmed that SA-1@MG effectively suppressed fibrotic markers (ACTA2, COL1A1, TIMP1, TGFB1), demonstrating enhanced antifibrotic activity compared to free MG. These results highlight SA-1@MG as a dual-functional platform for Fe³⁺ fluorescence detection and hepatic fibrosis therapy, providing a promising strategy for early diagnosis and treatment of liver fibrosis.

Graphical Abstract