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<p>Azithromycin (AZM) is regarded as a potential risk to human immunity and ecosystems, which requires an effective method for rapid on-site detection. Herein, a bifunctional monomer molecularly imprinted polymer and boronic acid-functionalized carbon dots (B-CDs) have been applied to develop an innovative sensor for the determination of AZM. The synergistic effects of boronic esters formation by boronic acid groups and non-covalent interaction of imprinted cavities by pyrrole enhance the binding affinity for improved recognition. In addition, the electrode modification strategy of B-CDs and multiwalled carbon nanotube (MWCNTs) enhance the electron transportation. The constructed sensor exhibited a broad linear detection range (0.2–300 µM), low detection limit (0.12 µM) and significant specificity for AZM (IF = 3.01). Furthermore, it showed satisfactory stability, repeatability and resistance to interference, enabling accurate detection of AZM in milk, serum and urine. This work provides a new avenue for the development of tailored sensitive electrochemical sensors to achieve specific detection.</p> Graphical Abstract <p></p>

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A bifunctional monomer molecularly imprinted sensor modified with boronic acid-functionalized carbon dots for detecting azithromycin

  • 期刊论文

  • 发表日期：

    2025年11月28日

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  • Hao-Xiang Wen,
  • Yan-Jun Li,
  • Fu-Lan Xiao,
  • Yu-Yu Deng,
  • Lian-Di D. Zhou,
  • Yang Mu,
  • Qi-Hui H. Zhang,
  • Chun-Su Yuan

摘要

Azithromycin (AZM) is regarded as a potential risk to human immunity and ecosystems, which requires an effective method for rapid on-site detection. Herein, a bifunctional monomer molecularly imprinted polymer and boronic acid-functionalized carbon dots (B-CDs) have been applied to develop an innovative sensor for the determination of AZM. The synergistic effects of boronic esters formation by boronic acid groups and non-covalent interaction of imprinted cavities by pyrrole enhance the binding affinity for improved recognition. In addition, the electrode modification strategy of B-CDs and multiwalled carbon nanotube (MWCNTs) enhance the electron transportation. The constructed sensor exhibited a broad linear detection range (0.2–300 µM), low detection limit (0.12 µM) and significant specificity for AZM (IF = 3.01). Furthermore, it showed satisfactory stability, repeatability and resistance to interference, enabling accurate detection of AZM in milk, serum and urine. This work provides a new avenue for the development of tailored sensitive electrochemical sensors to achieve specific detection.

Graphical Abstract