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<p>As the most active antioxidant in the flavonol family, quercetin (QR) exhibits favorable biochemical and pharmacological properties. Therefore, rapid and accurate determination of QR is of great importance. In this study, a π-conjugated molecule, 2,3,6,7,10,11-hexahydroxytriphenylene (HHTP) was employed to in-situ grow a conductive metal-organic framework (MOF) on CuCo-zeolitic imidazolate framework (CuCo-ZIF) by a simple one-step solvothermal coating method. This design enhances electron transfer, ultimately yielding a bimetallic MOF-on-MOF hybrid material (CuCo-ZIF@HHTP). The introduction of Cu improves the conductivity of the ZIF framework, while the π-π conjugation characteristic of HHTP further boosts the electrocatalytic performance of CuCo-ZIF. As an electroctalytic eletrode, an electrochemical sensor for sensitive detection of QR was developed, which exhibited excellent linear responses in two concentration ranges (0.25–35 µM and 35–155 µM) with an extremely low limit of detection (LOD) of 7.5 nM (S/<i>N</i> = 3). The sensor also demonstrated high selectivity and reproducibility, with successful application in the quantification of QR in food samples.</p> Graphical Abstract <p> A π-conjugated HHTP was coated on CuCo-ZIF via one-step solvothermal method to form CuCo-ZIF@HHTP with Cu enhancing conductivity and HHTP's π-π conjugation boosting electrocatalysis for sensitive QR detection in food samples.</p> <p></p>

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Construction of an enhanced electrochemical sensor for quercetin in food samples via binary MOF on MOF hybrids

  • 期刊论文

  • 发表日期：

    2025年11月25日

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  • Jianlong Li,
  • Jinmi Zhang,
  • Maoyuan Hu,
  • Yao Jin,
  • Sheng Li,
  • Xiaoli Xiong

摘要

As the most active antioxidant in the flavonol family, quercetin (QR) exhibits favorable biochemical and pharmacological properties. Therefore, rapid and accurate determination of QR is of great importance. In this study, a π-conjugated molecule, 2,3,6,7,10,11-hexahydroxytriphenylene (HHTP) was employed to in-situ grow a conductive metal-organic framework (MOF) on CuCo-zeolitic imidazolate framework (CuCo-ZIF) by a simple one-step solvothermal coating method. This design enhances electron transfer, ultimately yielding a bimetallic MOF-on-MOF hybrid material (CuCo-ZIF@HHTP). The introduction of Cu improves the conductivity of the ZIF framework, while the π-π conjugation characteristic of HHTP further boosts the electrocatalytic performance of CuCo-ZIF. As an electroctalytic eletrode, an electrochemical sensor for sensitive detection of QR was developed, which exhibited excellent linear responses in two concentration ranges (0.25–35 µM and 35–155 µM) with an extremely low limit of detection (LOD) of 7.5 nM (S/N = 3). The sensor also demonstrated high selectivity and reproducibility, with successful application in the quantification of QR in food samples.

Graphical Abstract

A π-conjugated HHTP was coated on CuCo-ZIF via one-step solvothermal method to form CuCo-ZIF@HHTP with Cu enhancing conductivity and HHTP's π-π conjugation boosting electrocatalysis for sensitive QR detection in food samples.