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<p>A&#xa0;novel metal–organic framework (MOF) supported Au nanoparticles (AuNPs)-based molecular imprinted electrochemical sensor (Au-MIECS) has been designed specifically for the detection of metformin&#xa0;(MET). Coupling different MOFs to form MOF-on-MOF structures can provide atomic charge transport channels, promote directional charge transfer and enhance electrochemical performance. To our knowledge, a combination of MOF-on-MOF and MIECS has not been reported. This is the first report on the preparation of MIECS based on MOF-on-MOF architecture. The synergistic effect of high electrical conductivity of AuNPs and the specificity of imprinting sites achieved excellent recognition to MET&#xa0;. The designed ultra-sensitive electrochemical sensor showed rapid response, excellent selectivity and wide linear range of 0.005–80&#xa0;μM with a low detection limit of 1.911&#xa0;nM.</p> Graphical Abstract <p></p>

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A novel molecularly imprinted sensor based on MOF-on-MOF architecture and Au nanoparticles for high-sensitivity electrochemical sensing of metformin

  • 期刊论文

  • 发表日期：

    2025年10月31日

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  • Xin Zhang,
  • Shuang Han,
  • Yuan Wang,
  • Chen Yan,
  • Jiaying Yu,
  • Xiaoyao Xie,
  • Jiayi Song,
  • Hongtao Chu,
  • Wei Zong

摘要

A novel metal–organic framework (MOF) supported Au nanoparticles (AuNPs)-based molecular imprinted electrochemical sensor (Au-MIECS) has been designed specifically for the detection of metformin (MET). Coupling different MOFs to form MOF-on-MOF structures can provide atomic charge transport channels, promote directional charge transfer and enhance electrochemical performance. To our knowledge, a combination of MOF-on-MOF and MIECS has not been reported. This is the first report on the preparation of MIECS based on MOF-on-MOF architecture. The synergistic effect of high electrical conductivity of AuNPs and the specificity of imprinting sites achieved excellent recognition to MET . The designed ultra-sensitive electrochemical sensor showed rapid response, excellent selectivity and wide linear range of 0.005–80 μM with a low detection limit of 1.911 nM.

Graphical Abstract