Scholarlink

<p>Dendritic polymer-based unimolecular micelles have attracted more interest in tumor chemotherapy. However, the drug release behavior was significantly affected by the hydrophilic-hydrophobic property of the dendritic cores. In the present work, carbon quantum dot (CQD) was used as a bridge between the dendritic core and drug to achieve a better drug release performance for imaging-mediated therapy. Strawberry-shaped hybrid prodrug was designed with a&#xa0;DOX content of 16.7%. The resultant hybrid unimolecular micelles with a mean hydrodynamic diameter of around 82&#xa0;nm showed sustained acid-triggered DOX release with minimized drug leakage, possessing enhanced anti-tumor efficacy compared to free DOX. Furthermore, the fluorescence of the hybrid unimolecular micelles could be turned on for imaging-guided cancer therapy after tumor intracellular drug release.</p> Graphical Abstract <p></p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Strawberry-shaped hybrid dendritic prodrug-based unimolecular micelles for improved drug release performance and real-time in-site fluorescence imaging

  • 期刊论文

  • 发表日期：

    2025年9月18日

查看全文
  • Wei Chen,
  • Peng Liu

摘要

Dendritic polymer-based unimolecular micelles have attracted more interest in tumor chemotherapy. However, the drug release behavior was significantly affected by the hydrophilic-hydrophobic property of the dendritic cores. In the present work, carbon quantum dot (CQD) was used as a bridge between the dendritic core and drug to achieve a better drug release performance for imaging-mediated therapy. Strawberry-shaped hybrid prodrug was designed with a DOX content of 16.7%. The resultant hybrid unimolecular micelles with a mean hydrodynamic diameter of around 82 nm showed sustained acid-triggered DOX release with minimized drug leakage, possessing enhanced anti-tumor efficacy compared to free DOX. Furthermore, the fluorescence of the hybrid unimolecular micelles could be turned on for imaging-guided cancer therapy after tumor intracellular drug release.

Graphical Abstract