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<p>An&#xa0;Ag<sup>+</sup>-functionalized structural color hydrogel (Ag<sup>+</sup>-SCH) sensor is constructed for colorimetric detection of glutathione (GSH). The hydrogel is prepared by using the coordination of Ag<sup>+</sup> and 1-vinylimidazole (1-VI) as cross-linking network. GSH acts as a competitive ligand to break the coordination between Ag<sup>+</sup> and 1-VI, leading to the expansion and structural color change of the hydrogel. Quantification was achieved by measuring particle spacing changes, yielding a dynamic range of 0.1–200&#xa0;μM with a limit of detection (LOD) of 0.04&#xa0;μM. Alternatively, smartphone-based hue analysis enables sensitive GSH detection with a LOD of 0.79&#xa0;μM. The sensor has proven to show high selectivity, excellent reusability, and long-term stability. In human serum tests, the Ag<sup>+</sup>-SCH performed comparably to commercial kits, while offering significantly lower cost. This portable, low-cost platform meets practical needs for GSH monitoring in diverse settings.</p> Graphical abstract <p></p>

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Construction of an Ag+-functionalized structural color hydrogel sensor for colorimetric detection of glutathione

  • 期刊论文

  • 发表日期：

    2025年9月10日

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  • Qianqian Feng,
  • Jiang Zhou,
  • Lingfeng Wang,
  • Xiaojiao Gong,
  • Qiang Xi,
  • Shengyuan Yang,
  • Wenfang Du,
  • Fubing Xiao

摘要

An Ag+-functionalized structural color hydrogel (Ag+-SCH) sensor is constructed for colorimetric detection of glutathione (GSH). The hydrogel is prepared by using the coordination of Ag+ and 1-vinylimidazole (1-VI) as cross-linking network. GSH acts as a competitive ligand to break the coordination between Ag+ and 1-VI, leading to the expansion and structural color change of the hydrogel. Quantification was achieved by measuring particle spacing changes, yielding a dynamic range of 0.1–200 μM with a limit of detection (LOD) of 0.04 μM. Alternatively, smartphone-based hue analysis enables sensitive GSH detection with a LOD of 0.79 μM. The sensor has proven to show high selectivity, excellent reusability, and long-term stability. In human serum tests, the Ag+-SCH performed comparably to commercial kits, while offering significantly lower cost. This portable, low-cost platform meets practical needs for GSH monitoring in diverse settings.

Graphical abstract