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<p>It is essential to develop an innovative technology with high sensitivity and real-time detection for the early diagnosis of ovarian cancer. The cross-disciplinary application of multifunctional materials represents a significant trend in contemporary sensing research. In this paper, a ratio-type fluorescence sensing platform RhB/TFBBPY-COF@PBA was constructed from the covalent organic framework (COF) co-functionalized by phenylboric acid and rhodamine B (RhB).&#xa0;Rapid, sensitive, and accurate detection was achieved&#xa0;of ovarian cancer biomarker, sialic acid (SA) with a wide linear range of 0.5–400&#xa0;μM, and low limit of detection (LOD) of 0.53&#xa0;μM. Furthermore, a simple and convenient smartphone-assisted colorimetric sensing mode was developed by analyzing changes in fluorescence RGB values, enabling on-site detection of SA without professional instrument with a LOD of 3.66&#xa0;μM. In addition, the dynamic fluorescence response of the RhB/TFBBPY-COF@PBA composite probe to SA stimulation was still utilized to design optical anti-counterfeiting labels, enabling information encryption in anti-counterfeiting. This research overcomes the limitations associated with the single functionality of traditional sensing materials and establishes a new paradigm for the application of COF materials in the triad of disease diagnosis, on-site detection, and information security. It is significant for the integration and development of precision medicine and smart materials.</p> Graphical Abstract <p></p>

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Multimodal sensing system based on phenylboric acid-COF/RhB ratio fluorescence: highly sensitive detection of ovarian cancer biomarker, smartphone-assisted field analysis and information encryption and anti-counterfeiting integration

  • 期刊论文

  • 发表日期：

    2025年8月4日

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  • Yanyan Ma,
  • Yuli Wei,
  • Hao Guo,
  • Yingfei Hui,
  • Liping Peng,
  • Dengke Zhuang,
  • Wenting Niu,
  • Yu Yan,
  • Yanrui Hao,
  • Wu Yang

摘要

It is essential to develop an innovative technology with high sensitivity and real-time detection for the early diagnosis of ovarian cancer. The cross-disciplinary application of multifunctional materials represents a significant trend in contemporary sensing research. In this paper, a ratio-type fluorescence sensing platform RhB/TFBBPY-COF@PBA was constructed from the covalent organic framework (COF) co-functionalized by phenylboric acid and rhodamine B (RhB). Rapid, sensitive, and accurate detection was achieved of ovarian cancer biomarker, sialic acid (SA) with a wide linear range of 0.5–400 μM, and low limit of detection (LOD) of 0.53 μM. Furthermore, a simple and convenient smartphone-assisted colorimetric sensing mode was developed by analyzing changes in fluorescence RGB values, enabling on-site detection of SA without professional instrument with a LOD of 3.66 μM. In addition, the dynamic fluorescence response of the RhB/TFBBPY-COF@PBA composite probe to SA stimulation was still utilized to design optical anti-counterfeiting labels, enabling information encryption in anti-counterfeiting. This research overcomes the limitations associated with the single functionality of traditional sensing materials and establishes a new paradigm for the application of COF materials in the triad of disease diagnosis, on-site detection, and information security. It is significant for the integration and development of precision medicine and smart materials.

Graphical Abstract