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<p>Zinc-based metal–organic framework (Zn-MOF), has been demonstrated to be&#xa0;a&#xa0;promising electrochemiluminescence (ECL) luminophore, owing to its tunable structures and functional versatility. It exhibited voltage-dependent ECL enhancement, however, repeated high-potential cycling induced progressive signal instability due to conductive band electron accumulation, which reduced electron–hole recombination efficiency and accelerated electrode passivation. Herein, SnS<sub>2</sub> QDs (quantum dots) decorated Zn-MOF (SnS<sub>2</sub> QDs@Zn-MOF) was synthesized and employed as the efficient luminophore. SnS<sub>2</sub> QDs, serving as electron acceptors, effectively trap over-injected electrons to prevent electrode passivation. Upon target binding, the ECL signal was quenched by dopaminequinone&#xa0;(DQ), which is the electro-oxidation product of dopamine. The resulting biosensor exhibited a broad linear range from 0.1&#xa0;nM to 100&#xa0;μM and an ultralow detection limit of 0.072&#xa0;nM. Overall, this work provides a promising strategy for the development of high-performance ECL biosensors.</p> Graphical Abstract <p></p>

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Surface passivation suppression in Zn-MOF for enhanced ECL sensing

  • 期刊论文

  • 发表日期：

    2025年7月5日

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  • Zifeng Li,
  • Wenqian Luo,
  • Jinjin Li,
  • Zhuoni Zhang,
  • Huixin Jian,
  • Yuqi Hu,
  • Ling Chen,
  • Dianping Tang,
  • Juan Tang

摘要

Zinc-based metal–organic framework (Zn-MOF), has been demonstrated to be a promising electrochemiluminescence (ECL) luminophore, owing to its tunable structures and functional versatility. It exhibited voltage-dependent ECL enhancement, however, repeated high-potential cycling induced progressive signal instability due to conductive band electron accumulation, which reduced electron–hole recombination efficiency and accelerated electrode passivation. Herein, SnS2 QDs (quantum dots) decorated Zn-MOF (SnS2 QDs@Zn-MOF) was synthesized and employed as the efficient luminophore. SnS2 QDs, serving as electron acceptors, effectively trap over-injected electrons to prevent electrode passivation. Upon target binding, the ECL signal was quenched by dopaminequinone (DQ), which is the electro-oxidation product of dopamine. The resulting biosensor exhibited a broad linear range from 0.1 nM to 100 μM and an ultralow detection limit of 0.072 nM. Overall, this work provides a promising strategy for the development of high-performance ECL biosensors.

Graphical Abstract